SLIGRL-NH2 A PAR2-activating agonist peptide

SLIGRL-NH2 (CAS 171436-38-7)

SLIGRL-NH2 | CAS 171436-38-7 is rated 5.0 out of 5 by 1.
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Synonym: seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide
Application: A PAR2-activating agonist peptide
CAS Number: 171436-38-7
Molecular Weight: 656.82
Molecular Formula: C29H56N10O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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SLIGRL-NH2 is a PAR2-activating peptide.


References

1. Kawabata, A., et al. 2001. Br. J. Pharmacol. 133: 1213-1218. PMID: 11498505
2. Kawao, N., et al. 2002. Br. J. Pharmacol. 135: 1292-1296. PMID: 11877338

Physical State :
Solid
Sequence :
H-Ser-Leu-Ile-Gly-Arg-Leu-NH2
Solubility :
Soluble in water (1 mg/ml).
Storage :
Desiccate at -20° C
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Activates PAR2: EC5050 = ~5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9831050
SMILES :
CC[C@H](C)[C@@H](C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shin Shin, YS. et al. (PubMed 26273149) examined the effect of the PAR2 agonist, SLIGRL-NH2, on cultured keratinocytes. Treatment with SLIGRL-NH2 increased loricrin and filaggrin expression, a terminal differentiation marker. -SCBT Publication Review
Date published: 2015-07-20
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