SKF 89976A hydrochlorideA potent GABA uptake inhibitor

SKF 89976A hydrochloride (CAS 85375-85-5)

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Application: A potent GABA uptake inhibitor
CAS Number: 85375-85-5
Molecular Weight: 371.9
Molecular Formula: C22H25NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SKF 89976A hydrochloride is a potent inhibitor of GABA (sc-203053) uptake. SKF 89976A is described to be highly selective for the GAT-1 (GABA T-1) protein, demonstrating high affinity at cloned human GABA T-1 (IC50 = 0.13 μM) and rat GABA T-1 (IC50 = 0.64 μM) for inhibition of [3H]GABA uptake with very low affinity at rat GABA T-2 (IC50 = 550 μm) and human GABA T-3 (IC50 = 944 μM).


References

1. Ali, F.E., et al. 1985. J. Med. Chem. 28: 653-660. PMID: 2985785
2. Borden, L.A., et al. 1994. Eur. J. Pharmacol. 269: 219-224. PMID: 7851497

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at 4° C
Melting Point :
314.73° C (Predicted)
Boiling Point :
531.36° C at 760 mmHg (Predicted)
Density :
1.12 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
GAT-1: IC50 = 0.13 µM (human); GAT-1: IC50 = 550 µM (rat); BGT-1: IC50 = 7210 µM (human); GAT-3: IC50 = 944 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
TM6241000
PubChem CID :
6917797
SMILES :
C1CC(CN(C1)CCC=C(C2=CC=CC=C2)C3=CC=CC=C3)C(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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