SIRT2 Inhibitor, AGK2 A reversible inhibitor of SIRT2 activity

SIRT2 Inhibitor, AGK2 (CAS 304896-28-4)

SIRT2 Inhibitor, AGK2 | CAS 304896-28-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_7, d_21, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202813, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 87ms
  • REVIEWS, PRODUCT
Synonym: 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-5-quinolinylacrylamide
Application: A reversible inhibitor of SIRT2 activity
CAS Number: 304896-28-4
Purity: ≥95%
Molecular Weight: 434.27
Molecular Formula: C23H13Cl2N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SIRT2 Inhibitor, AGK2 is a reversible inhibitor of sirtuin 2 (SIRT2), a histone deacetylase enzyme. Inhibition of SIRT2 has been correlated to protection against dopaminergic cell death in Parkinson's disease models, and is also shown to rescue cells from toxicity conferred by alpha-synuclein expression. SIRT2 Inhibitor, AGK2 has little activity against SIRT1 and SIRT3 (IC50 >50 μM).


References

1. Auluck, Pavan K., et al., 2002. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (New York, N.Y.). 295(5556): 865-8. PMID: 11823645
2. Outeiro, Tiago Fleming., et al., 2007. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317(5837): 516-9. PMID: 17588900

Physical State :
Solid
Solubility :
Soluble in DMSO (>5 mg/ml), DMF (3 mg/ml), and 1:2 DMF:PSB(pH 7.2) (0.3 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
283.64° C (Predicted)
Boiling Point :
675.09° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
sirtuin 2: IC50 = 3.5 µM; SIRT1/3: IC50 = >50 µM
pK Values :
pKa: 9.61 (Predicted), pKb: 4.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1183107
MDL Number :
MFCD01909444
SMILES :
C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

SIRT2 Inhibitor, AGK2  Product Citations

See how others have used SIRT2 Inhibitor, AGK2. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26022124  Binker, MG. et al. 2015. Biochemical and biophysical research communications. 463: 329-35.

PMID: # 20543840  Zhao, Y. et al. 2010. Nat. Cell Biol. 12: 665-675.

PMID: # 17588900  Outeiro, TF. et al. 2007. Science. 317: 516-519.

Citations 1 to 3 of 3 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 83ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Outeiro et al Outeiro et al. (PubMed ID 17588900) used the SIRT2 inhibitor, AGK2, to disrupt cell cycle regulation by inactivating SIRT2 s ability to deacetylate alpha-tubulin. -SCBT Publication Review
Date published: 2015-05-02
  • y_2019, m_7, d_21, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_202813, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 79ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.