SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.
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See how others have used SIRT1 Activator 3. Click on the entry to view the PubMed entry .
PMID: # 27878231
Lu, H. et al. 2017. SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22. Int. J. Mol. Med.. 39: 208-216.
PMID: # 25707573
Wei, J. et al. 2015. The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. 67: 1323-34.
PMID: # 24009212
Ahn, J. et al. 2013. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 5: 1602-12.
PMID: # 12202400
Lokshin, AE. et al. 2002. Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. Int. Immunol.. 14: 1027-37.
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