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SIRT1 Activator 3 (CAS 839699-72-8)

SIRT1 Activator 3 | CAS 839699-72-8 is rated 5.0 out of 5 by 1.

| See product citations (4)

Synonym: Sirtuin 1 Activator 3

Application: A SIRT1 activator which also inhibits TNF-α

CAS Number: 839699-72-8

Molecular Weight: 367.44

Molecular Formula: C₂₀H₂₅N₅O₂

* Refer to Certificate of Analysis for lot specific data (including water content).

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Ordering Information

PRODUCT NAME	CATALOG #	UNIT	PRICE	QTY		FAVORITES
SIRT1 Activator 3	sc-222315	1 mg	$102.00
SIRT1 Activator 3	sc-222315A	5 mg	$349.00

SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.

References

1. Nayagam, V.M., et al. 2006. J Biomol Screen. 11: 959-967. PMID: 17099246
2. Seo, J.S., et al. 2010. Neurobiol. Aging. . [Epub ahead of print]. PMID: 21074897

Physical State :

Solid

Solubility :

Soluble in water (0.5 mg/ml at 25° C), ethanol (~1 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and 1:1 solution of DMF:PBS (pH 7.2 (~0.5 mg/ml).

Storage :

Store at -20° C

Melting Point :

259.71° C (Predicted)

Boiling Point :

~651.4° C at 760 mmHg (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.69 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

1882365

MDL Number :

MFCD03692733

SMILES :

COCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C(=O)NC4CCCC4)N

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Certificate of Analysis

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SIRT1 Activator 3Product Citations

See how others have used SIRT1 Activator 3. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27878231
Lu, H. et al. 2017. SIRT1 exerts neuroprotective effects by attenuating cerebral ischemia/reperfusion-induced injury via targeting p53/microRNA-22. Int. J. Mol. Med.. 39: 208-216.

PMID: # 25707573
Wei, J. et al. 2015. The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling. 67: 1323-34.

PMID: # 24009212
Ahn, J. et al. 2013. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade. EMBO Mol Med. 5: 1602-12.

PMID: # 12202400
Lokshin, AE. et al. 2002. Differential regulation of maturation and apoptosis of human monocyte-derived dendritic cells mediated by MHC class II. Int. Immunol.. 14: 1027-37.

Citations 1 to 4 of 4 total

Rated 5 out of 5 by MS from Ponnusamy Ponnusamy, M. et al. (PubMed 26022003) found that activation of SIRT-1 via SIRT-1 activators, such as SIRT1 Activator 3, can provoke renal fibrogenesis through a mechanism involved in the activation of EGFR and PDGFR signaling pathways. -SCBT Publication Review

Date published: 2015-05-28

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