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SIRT1 Activator 3 (CAS 839699-72-8)

SIRT1 Activator 3 | CAS 839699-72-8 is rated 5.0 out of 5 by 1.

See product citations (6)

Synonym: Sirtuin 1 Activator 3

Application: A SIRT1 activator which also inhibits TNF-α

CAS Number: 839699-72-8

Molecular Weight: 367.44

Molecular Formula: C₂₀H₂₅N₅O₂

* Refer to Certificate of Analysis for lot specific data (including water content).

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SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.

References

1. Nayagam, V.M., et al. 2006. J Biomol Screen. 11: 959-967. PMID: 17099246
2. Seo, J.S., et al. 2010. Neurobiol. Aging. . [Epub ahead of print]. PMID: 21074897

Physical State :

Solid

Solubility :

Soluble in water (0.5 mg/ml at 25° C), ethanol (~1 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and 1:1 solution of DMF:PBS (pH 7.2 (~0.5 mg/ml).

Storage :

Store at -20° C

Melting Point :

259.71° C (Predicted)

Boiling Point :

~651.4° C at 760 mmHg (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.69 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

1882365

MDL Number :

MFCD03692733

SMILES :

COCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C(=O)NC4CCCC4)N

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Certificate of Analysis

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SIRT1 Activator 3 Product Citations

See how others have used SIRT1 Activator 3. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27878231 Lu, H. et al. 2017. Int. J. Mol. Med. 39: 208-216.

PMID: # 25707573 Wei, J. et al. 2015. 67: 1323-34.

PMID: # 24009212 Ahn, J. et al. 2013. EMBO Mol Med. 5: 1602-12.

PMID: # 23723308 Hernández-Jiménez, M. et al. 2013. Stroke. 44: 2333-7.

PMID: # 23056314 Miyashita, H. et al. 2012. PLoS ONE. 7: e46459.

PMID: # 12202400 Lokshin, AE. et al. 2002. Int. Immunol. 14: 1027-37.

Citations 1 to 6 of 6 total

Rated 5 out of 5 by MS from Ponnusamy Ponnusamy, M. et al. (PubMed 26022003) found that activation of SIRT-1 via SIRT-1 activators, such as SIRT1 Activator 3, can provoke renal fibrogenesis through a mechanism involved in the activation of EGFR and PDGFR signaling pathways. -SCBT Publication Review

Date published: 2015-05-28

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SIRT1 Activator 3 (CAS 839699-72-8)

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References

Download SDS (MSDS)

Certificate of Analysis

SIRT1 Activator 3 Product Citations

SIRT1 Activator 3 (CAS 839699-72-8)

QUICK LINKS

References

Download SDS (MSDS)

Certificate of Analysis

SIRT1 Activator 3 Product Citations

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