SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.
1. Nayagam, V.M., et al. 2006. J Biomol Screen. 11: 959-967. PMID: 17099246 2. Seo, J.S., et al. 2010. Neurobiol. Aging. . [Epub ahead of print]. PMID: 21074897
Soluble in water (0.5 mg/ml at 25° C), ethanol (~1 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and 1:1 solution of DMF:PBS (pH 7.2 (~0.5 mg/ml).
Store at -20° C
259.71° C (Predicted)
~651.4° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SIRT1 Activator 3
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PonnusamyPonnusamy, M. et al. (PubMed 26022003) found that activation of SIRT-1 via SIRT-1 activators, such as SIRT1 Activator 3, can provoke renal fibrogenesis through a mechanism involved in the activation of EGFR and PDGFR signaling pathways. -SCBT Publication Review
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