SIRT1 Activator 3 A SIRT1 activator which also inhibits TNF-α

SIRT1 Activator 3 (CAS 839699-72-8)

SIRT1 Activator 3 | CAS 839699-72-8 is rated 5.0 out of 5 by 1.
  • y_2018, m_10, d_21, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_222315, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 40ms
  • REVIEWS, PRODUCT
| See product citations (4)
Synonym: Sirtuin 1 Activator 3
Application: A SIRT1 activator which also inhibits TNF-α
CAS Number: 839699-72-8
Molecular Weight: 367.44
Molecular Formula: C20H25N5O2
* Refer to Certificate of Analysis for lot specific data (including water content).
submit a review for this product and receive 15 cruzcredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
SIRT1 Activator 3 sc-222315 1 mg $102.00
SIRT1 Activator 3 sc-222315A 5 mg $349.00

SIRT1 Activator 3 is a member of the sirtuins (SIRTs), a distinctive class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). Human SIRT1 is the homolog of yeast silent information regulator 2 (Sir2) and has been illustrated to regulate the activity of the p53 tumor suppressor and inhibit apoptosis. This compound has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. In THP-1 cells, TNF-α levels decreased from 325 ρg/ml (control) to 104 and 53 ρg/ml with 20 and 60 μM of SIRT1 Activator 3, respectively. This activator also has shown a significant dose-dependent effect on fat mobilization in differentiated adipocytes, which indicates the potential of SIRT1 activators for obesity research, and may inhibit neurotoxicity of the prion protein.


References

1. Nayagam, V.M., et al. 2006. J Biomol Screen. 11: 959-967. PMID: 17099246
2. Seo, J.S., et al. 2010. Neurobiol. Aging. . [Epub ahead of print]. PMID: 21074897

Physical State :
Solid
Solubility :
Soluble in water (0.5 mg/ml at 25° C), ethanol (~1 mg/ml), DMSO (~20 mg/ml), DMF (~30 mg/ml), and 1:1 solution of DMF:PBS (pH 7.2 (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
259.71° C (Predicted)
Boiling Point :
~651.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1882365
MDL Number :
MFCD03692733
SMILES :
COCCCN1C(=C(C2=NC3=CC=CC=C3N=C21)C(=O)NC4CCCC4)N

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

SIRT1 Activator 3Product Citations

See how others have used SIRT1 Activator 3. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 27878231  Lu, H. et al. 2017. Int. J. Mol. Med. 39: 208-216.

PMID: # 25707573  Wei, J. et al. 2015. 67: 1323-34.

PMID: # 24009212  Ahn, J. et al. 2013. EMBO Mol Med. 5: 1602-12.

PMID: # 12202400  Lokshin, AE. et al. 2002. Int. Immunol. 14: 1027-37.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 59ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Ponnusamy Ponnusamy, M. et al. (PubMed 26022003) found that activation of SIRT-1 via SIRT-1 activators, such as SIRT1 Activator 3, can provoke renal fibrogenesis through a mechanism involved in the activation of EGFR and PDGFR signaling pathways. -SCBT Publication Review
Date published: 2015-05-28
  • y_2018, m_10, d_21, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_222315, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.