Sipholenol A An inhibitor of P-glycoprotein(MDR-1) function

Sipholenol A (CAS 78518-73-7)

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Synonym: (3R,5aR,6R,7S,9aR)-6-[2-[(1R,3aR,5S,8aR)-1-hydroxy-1,4,4, 6-tetramethyl-2,3,3a,5,8,8a-hexahydroazulen-5-yl]ethyl]-2,2,5a, 7-tetramethyl-4,5,6,8,9,9a-hexahydro-3H-benzo[b]oxepine-3,7-diol
Application: An inhibitor of P-glycoprotein(MDR-1) function
CAS Number: 78518-73-7
Molecular Weight: 476.73
Molecular Formula: C30H52O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sipholenol A efficiently inhibits the function of P-glycoprotein (Pgp, MDR-1). It is a new reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. This has antiproliferative activity, and is cytotoxic. By inhibiting MDR-1, active compounds remain in the cytoplasm longer, allowing them to be more effective within the cell.


References

S. Carmely & Y. Kashman; J. Org. Chem. 48, 3517 (1983). S. Jain, et al.; J. Nat. Prod. 70, 928 (2007). Z. Shi, et al.; Cancer Sci. 98, 1373 (2007). S. Jain, et al.; Planta Med. 73, 591 (2007).

Appearance :
Powder
Physical State :
Solid
Derived From :
Synthetic
Solubility :
Soluble in DMSO or 100% ethanol (25mg/ml).
Storage :
Store at room temperature
Melting Point :
230.02° C (Predicted)
Boiling Point :
~572.3° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
342374
SMILES :
CC1=CC[C@@H]2[C@@H](CC[C@@]2(C)O)C([C@H]1CC[C@@H]3[C@]4(CC[C@H](C(O[C@@H]4CC[C@]3(C)O)(C)C)O)C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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