Sinomenine hydrochloride is a natural anti-inflammatory morphinan analog. Sinomenine hydrochloride causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Sinomenine hydrochloride also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.
1. Yamasaki, H., et al., 1976. Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta medica Okayama. 30(1): 1-20. PMID: 61710
2. Desbordes, Sabrina C., et al., 2008. High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell stem cell. 2(6): 602-12. PMID: 18522853
3. Wang, Mao Hsien., et al., 2008. Activation of opioid mu-receptor by sinomenine in cell and mice. Neuroscience letters. 443(3): 209-12. PMID: 18692550
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