Sinefungin A SAM analog and Dnmt inhibitor

Sinefungin (CAS 58944-73-3)

Sinefungin | CAS 58944-73-3 is rated 5.0 out of 5 by 1.
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Synonym: Adenosylornithine
Application: A SAM analog and Dnmt inhibitor
CAS Number: 58944-73-3
Purity: >95%
Molecular Weight: 381.39
Molecular Formula: C15H23N7O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sinefungin is a DNA methyltransferase (Dnmt) inhibitor and an analog of s-adenosyl-L-methionine (SAM) as indicated by previous studies. In studies investigating cytosine deamination by Dnmt, it was noted that the presence of sinefungin increased the rate of deamination 103 fold in the presence of its analog SAM, and 104 in the absence of SAM. This may suggest that sinefungin could be useful as a test compound in antiviral, anticancer, antiparasitic and antifungal applications. Additional studies indicate that sinefungin was able to inhibit RNA synthesis in a vaccinia virion preparation.


References

1. Pugh, C.S., et al. 1978. J. Biol. Chem. 253: 4075-4077. PMID: 659406
2. Zingg, J.M., et al. 1996. Nucleic Acids Res. 24: 3267-3275. PMID: 8774911
3. Lin, Q., et al. 2001. J. Am. Chem. Soc. 123: 11608-11613. PMID: 11716715
4. Cheng, D., et al. 2004. J. Biol. Chem. 279: 23892-23899. PMID: 15056663

Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at -20° C
Melting Point :
336.70° C (Predicted)
Boiling Point :
783.23° C at 760 mmHg (Predicted)
Density :
1.91 g/cm3 (Predicted)
Refractive Index :
n20D 1.83 (Predicted)
IC50 :
(PRMT1) Protein-arginine N-methyltransferase 1: IC50 = <1 µM (human); Leishmania donovani: IC50 = 1 µM (Leishmania donovani); (SET7/9) Histone-lysine N-methyltransferase SETD7: IC50 = 2.5 µM (human)
pK Values :
pKa: 2.44 (Predicted), pKb: 10.51 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
HE3140000
PubChem CID :
4065234
Merck Index :
14: 8544
MDL Number :
MFCD00057013
SMILES :
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O

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Certificate of Analysis

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Sinefungin  Product Citations

See how others have used Sinefungin. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26202969  Liu, RJ. et al. 2015. Nucleic acids research. 43: 7489-503.

PMID: # 25050323  Yadav, MK. et al. 2014. BioMed research international. 2014: 156987.

PMID: # 24128079  Fu, X. et al. 2014. Mol Ecol Resour. 14: 184-98.

Citations 1 to 3 of 3 total

What is the shipping temperature of this product?

Asked by: hawkeye11
This chemical, Sinefungin (CAS 58944-73-3), ships ambient.
Answered by: Chemical Support 1
Date published: 2017-03-30
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Rated 5 out of 5 by from Yadav Yadav, MK. et al. (PubMed 25050323) found that Sinefungin, a DNA methyltransferase inhibitor and an analog of s-adenosyl-L-methionine (SAM, AdoMet), inhibited Streptococcus pneumoniae biofilm growth. -SCBT Publication Review
Date published: 2015-06-29
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