Scriptaid is an HDAC inhibitor (histone deacetylase). HDACs are modifying enzymes that are involved in the regulation of gene transcription, cell proliferation, and chromosome remodeling. Scriptaid has been reported to inhibit all three class I HDACs (HDAC1, HDAC3, HDAC8). Breast cancer cell studies demonstrate that Scriptaid, in combination with 5-Aza-2′-Deoxycytidine (sc-202424), elevates the expression of the estrogen receptor α. Scriptaid has been described to reactivate the latent HIV-1 promoter in Jurkat T cell lines, and elicit glioma cell apoptosis by activating JNK and blocking telomerase activity. Nullscript (sc-222084) serves as the negative control for Scriptaid.
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See how others have used Scriptaid. Click on the entry to view the PubMed entry .
PMID: # 26728316 Chan, CN. et al. 2016. Retrovirology. 13: 1.
PMID: # 25993039 Berghauser Pont, LM. et al. 2015. PLoS ONE. 10: e0127058.
PMID: # 25305451 Pont, LM. et al. 2015. Cancer Lett. 356: 525-35.
PMID: # 12975471 Kook, H. et al. 2003. J. Clin. Invest. 112: 863-871.
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