Scriptaid An HDAC1, HDAC3, and HDAC8 inhibitor

Scriptaid (CAS 287383-59-9)

Scriptaid | CAS 287383-59-9 is rated 5.0 out of 5 by 2.
  • y_2019, m_7, d_20, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202807, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 80ms
  • REVIEWS, PRODUCT
Synonym: 6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Application: An HDAC1, HDAC3, and HDAC8 inhibitor
CAS Number: 287383-59-9
Purity: >95%
Molecular Weight: 326.35
Molecular Formula: C18H18N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Scriptaid is an HDAC inhibitor (histone deacetylase). HDACs are modifying enzymes that are involved in the regulation of gene transcription, cell proliferation, and chromosome remodeling. Scriptaid has been reported to inhibit all three class I HDACs (HDAC1, HDAC3, HDAC8). Breast cancer cell studies demonstrate that Scriptaid, in combination with 5-Aza-2′-Deoxycytidine (sc-202424), elevates the expression of the estrogen receptor α. Scriptaid has been described to reactivate the latent HIV-1 promoter in Jurkat T cell lines, and elicit glioma cell apoptosis by activating JNK and blocking telomerase activity. Nullscript (sc-222084) serves as the negative control for Scriptaid.


References

1. Su, G.H., et al. 2000. Cancer Res. 60: 3137-3142. PMID: 10866300
2. Keen, J.C., et al. 2003. Breast Cancer Res. Treat. 81: 177-186. PMID: 14620913
3. Hu, E., et al. 2003. J. Pharmacol. Exp. Ther. 307: 720-728. PMID: 12975486
4. Ying, H., et al. 2010. Int. J. Mol. Med. 26: 265-272. PMID: 20596607
5. Sharma, V., et al. 2010. J. Cell. Mol. Med. 14: 2151-2161. PMID: 19583803

Usage :
Solutions can be made through stirring rapidly, sonicating, or warming (45-60° C water bath).
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), methanol, ethanol (0.3 mg/ml), and water (<1 mg/ml).
Storage :
Store at 4° C
Melting Point :
160-161° C
Boiling Point :
648.99° C (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
HDAC1 : IC50 = 0.6 µM; HDAC3: IC50 = 0.6 µM; HDAC8: IC50 = 1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5186
MDL Number :
MFCD00386477
SMILES :
C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CCCCCC(=O)NO

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Scriptaid  Product Citations

See how others have used Scriptaid. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 26728316  Chan, CN. et al. 2016. Retrovirology. 13: 1.

PMID: # 25993039  Berghauser Pont, LM. et al. 2015. PLoS ONE. 10: e0127058.

PMID: # 25305451  Pont, LM. et al. 2015. Cancer Lett. 356: 525-35.

PMID: # 12975471  Kook, H. et al. 2003. J. Clin. Invest. 112: 863-871.

Citations 1 to 4 of 4 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 69ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Nice Chemical Nice chemical and it works really well in my cells. Just want to know if it is soluble in PBS since it is does not work in my PBS injection aliquot
Date published: 2017-11-26
Rated 5 out of 5 by from An increase in Ac An increase in Ac-Histone H4 protein expression is observed by WB in A549 cells after treatment with Scriptaid. -SCBT QC
Date published: 2015-04-18
  • y_2019, m_7, d_20, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202807, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 79ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.