SCH 23390A selective and highly effective D1DR and D5DR antagonist

SCH 23390 (CAS 125941-87-9)

SCH 23390 | CAS 125941-87-9 is rated 5.0 out of 5 by 1.
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Synonym: R-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine•HCl
Application: A selective and highly effective D1DR and D5DR antagonist
CAS Number: 125941-87-9
Purity: 98%
Molecular Weight: 324.2
Molecular Formula: C17H18ClNO•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SCH 23390 is a selective and highly effective dopamine D1DR (D1 ) and D5DR (D5) receptor antagonist. In vitro studies reveal that SCH 23390 has the ability to bind to the serotonin receptors 5-HT2 and SR-2C (5-HT1C). SCH 23390 has been used to research the topographical determination of D1 receptors in brain studies of multiple species, and the dopamine system.


References

1. Bourne, J.A. 2001. CNS Drug Rev. 7: 399-414. PMID: 11830757
2. Noda, Y., et al. 2010. Int. J. Neuropsychopharmacol. 13: 1343-1354. PMID: 20219155

Physical State :
Solid
Solubility :
Soluble in water (8 mg/mL), DMSO (3 mg/mL), and ethanol (2 mg/mL).
Storage :
Store at -20° C
Optical Activity :
α20/D +32.1°, c = 1 in DMF
Ki Data :
dopamine D1 receptor: Ki= ~0.2 nM; dopamine D5 receptor: Ki= 0.3 nM; dopamine D2 receptor: Ki= ~1100 nM; dopamine D3 receptor: Ki= ~800 nM; dopamine D4 receptor: Ki= ~3000 nM; 5-HT 1C/2C receptors: Ki= 6.3 nM
pK Values :
pKa: 8.83 (Predicted), pKb: 8.08 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CX7256139
PubChem CID :
11957535
MDL Number :
MFCD00069249
SMILES :
CN1CCC2=CC(=C(C=C2[C@H](C1)C3=CC=CC=C3)O)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Noda et al Noda et al. (PubMed ID 20219155) found that SCH 23390 prevented the ameliorating effect of galantamine on Meth-induced memory impairment in mice via dopamine D1 receptor inhibition. -SCBT Publication Review
Date published: 2015-03-18
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