SC1 (Pluripotin) A sustainer of mES self-renewal and ERK 1 inhibitor

SC1 (Pluripotin) (CAS 839707-37-8)

SC1 (Pluripotin) | CAS 839707-37-8 is rated 5.0 out of 5 by 1.
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Synonym: N-(3-(7-(1,3-dimethyl-1H-pyrazol- 5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide
Application: A sustainer of mES self-renewal and ERK 1 inhibitor
CAS Number: 839707-37-8
Molecular Weight: 550.54
Molecular Formula: C27H25F3N8O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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SC1 is a small molecule shown to sustain self-renewal of mouse embryonic stem (mES) cells. In order to maintain embryonic stem cells in an undifferentiated state, it is typically necessary to use a combination of feeder cells, leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP); SC1 (Pluripotin) allows for stem cell propagation in the absence of these factors. The activity of SC1 is mediated by Ras signaling which promotes self-renewal, and inhibition of ERK blocks differentiation.


References

1. Chen, S., et al. 2006. Proc. Natl. Acad. Sci. U.S.A. 103: 17266-17271. PMID: 17088537
2. Xiong, W., et al. 2009. J Vis Exp. 18: PMID: 19924098

Physical State :
Solid
Solubility :
Soluble in water (0.3 mg/ml at 25° C), DMSO: PBS(1: 2) pH 7.2 (~0.3 mg/ml), DMF (~50 mg/ml), and DMSO (~25 mg/ml).
Storage :
Store at -20° C
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
12003241
MDL Number :
MFCD20527253
SMILES :
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)N3CC4=CN=C(N=C4N(C3=O)C)NC5=CC(=NN5C)C

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Certificate of Analysis

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Rated 5 out of 5 by from Du Du, et al. (PubMed ID 24556957) used SC1, an inhibitor of ERK-1 and RasGAP-dependent signaling pathways, to study cell morphological changes in embryonic carcinoma cells post treatment. -SCBT Publication Review
Date published: 2015-04-23
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