Sarafloxacin hydrochloride Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent.

Sarafloxacin hydrochloride  (CAS 91296-87-6)

Sarafloxacin hydrochloride is rated 5.0 out of 5 by 1.
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Synonym: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid . hydrochloride
Application: A fluoroquinolone antibacterial agent
CAS Number: 91296-87-6
Purity: ≥98%
Molecular Weight: 421.82
Molecular Formula: C20H17F2N3O3•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Sarafloxacin hydrochloride sc-203255 5 g $52.00
Sarafloxacin hydrochloride sc-203255A 25 g $170.00

Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent. Inhibits bacterial Topo II α (DNA gyrase, topoisomerase). Sarafloxacin hydrochloride is effective against Mycobacterium tuberculosis.


References

Synthesis and structure-activity relationships of novel arylfluoroquinolone antibacterial agents: D.T. Chu, et al.; J. Med. Chem. 28, 1558 (1985) In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones: P.B. Fernandes, et al.; Antimicrob. Agents Chemother. 29, 201 (1986) In-vitro activity of six fluorinated quinolones against Mycobacterium tuberculosis: O.G. Berlin, et al.; J. Antimicrob. Chemother. 19, 611 (1987) In vitro activities of A-56619 (difloxacin) and A-56620, two aryl fluoroquinolones: A. Digranes & W.L. Dibb; Chemotherapy 34, 298 (1988) Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography: J.F. Bauer, et al.; Pharm. Res. 7, 1177 (1990)

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), DMSO (1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
275° C
Boiling Point :
621.40° C
Refractive Index :
n20D 1.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
56207
Merck Index :
14: 8370
MDL Number :
MFCD03427297
SMILES :
C1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=CC=C(C=C4)F)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Yue Yue, Z. et al. (PubMed 17970104) developed a method utilizing high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (HPLC-MS/MS) to simultaneously detect 16 quinolone residues in animal tissues, which included Sarafloxacin. -SCBT Publication Review
Date published: 2015-03-26
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