Sanguinarine chloride A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor

Sanguinarine chloride (CAS 5578-73-4)

Sanguinarine chloride | CAS 5578-73-4 is rated 5.0 out of 5 by 2.
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Synonym: Pseudochelerythrine
Application: A benzophenanthridine alkaloid and potent, noncompetitive Na+/K+-and Mg2++-ATPase inhibitor
CAS Number: 5578-73-4
Purity: ≥98%
Molecular Weight: 367.8
Molecular Formula: C20H14NO4•Cl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sanguinarine chloride is a benzophenanthridine alkaloid and potent, noncompetitive sodium/Potassium-ATPase Protein Inhibitors (Na+/K+ ATPase) inhibitor with anticancer properties. This product has been observed to induce apoptosis in cultured C6 rat glioblastoma cells potentially via a downregulative ability of extracellular singal-regulated and Akt signaling pathways. It is reported that sanguinarine also inhibits protein phosphatase 2C (PP2) and induces human promyelocytic leukemia cell line HL60 apoptosis through the phosphorylation of p38, a PP2Cα substrate associated with caspase-3/7 activity. This compound posesses antimicrobial and anti-plaque qualities. Sanguinarine chloride is an inhibitor of MKP-1 and PP2.


References

1. Meyerson, L.R., et al. 1978. Neurochem. Res. 3: 239-257. PMID: 149928
2. Southard, G.L., et al. 1984. J Am Dent Assoc. 108: 338-341. PMID: 6585404
3. Debiton, E., et al. 2003. Cancer Chemother. Pharmacol. 51: 474-482. PMID: 12700925
4. Han, M.H., et al. 2007. Anticancer Drugs. 18: 913-921. PMID: 17667597
5. Aburai, N., et al. 2010. Biosci. Biotechnol. Biochem. 74: 548-552. PMID: 20208361

Physical State :
Solid
Derived From :
Isolated from the leaves and stems of Macleaya cordata and M. microcarpa.
Solubility :
Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM).
Storage :
Store at 4° C
Melting Point :
278-279° C
IC50 :
Plasmodium falciparum: IC50 = 2.51 µM; MKP-1: IC50 = 10 µM; Cell division control protein 42 homolog: IC50 = 32 µM (human); Ras-related C3 botulinum toxin substrate 1: IC50 = 58 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
VP5220000
PubChem CID :
68635
Merck Index :
14: 8356
MDL Number :
MFCD00012126
SMILES :
C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6.[Cl-]

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Certificate of Analysis

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Sanguinarine chloride  Product Citations

See how others have used Sanguinarine chloride. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 19246011  Selvi B, R. et al. 2009. Chem. Biol. 16: 203-216.

PMID: # 16964588  Malíková, J. et al. 2006. Cell Biol. Toxicol. 22: 439-453.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from expected result good inhibitor for funtional study , I have used ever, good expected result.
Date published: 2017-05-28
Rated 5 out of 5 by from Aburai et al Aburai et al. (PubMed ID 20208361) found that the protein phosphatase inhibitor, Sanguinarine chloride,showed cytotoxicity towards human promyelocytic leukemia cell line HL60 and also induced apoptosis via caspase 3 and 7. -SCBT Publication Review
Date published: 2015-06-20
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