Salubrinal is a cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50~15μM) in PC12 cell lines induced with the protein glycosylation inhibitor tunicamycin (sc-201539), and brefeldin A (sc-200861), which causes ER stress by blocking ER-to-Golgi vesicle transport. Salubrinal is a potentially useful agent to study mechanisms of ER stress-induced apoptosis.
1. Boyce, M., et al. 2005. Science. 307: 935-939. PMID: 15705855 2. Boyce, M., et al. 2008. Cell Death Differ. 15: 589-599. PMID: 18188169 3. Razi, M., et al. 2009. J. Cell Biol. 185: 305-321. PMID: 19364919
Soluble in DMSO (96 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (2 mg/ml at 25° C).
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
We used this several times in our lab andWe used this several times in our lab and got good results.
Date published: 2015-08-26
Rated 5 out of
KK-562 cells were treated with with both lambda protein phosphatase and Salubrinal, followed by WB analysis. The presence of Salubrinal has prevented lambda protein phosphatase from de-phosphorylating p-Cofilin 1. -SCBT QC
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.