Salubrinal A selective inhibitor of eIF-2α used to study ER stress-induced apoptosis

Salubrinal (CAS 405060-95-9)

Salubrinal | CAS 405060-95-9 is rated 5.0 out of 5 by 2.
  • y_2018, m_5, d_25, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202332, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 228ms
  • REVIEWS, PRODUCT
| See product citations (51)
Synonym: eIF-2α Inhibitor
Application: A selective inhibitor of eIF-2α used to study ER stress-induced apoptosis
CAS Number: 405060-95-9
Purity: ≥98%
Molecular Weight: 479.81
Molecular Formula: C21H17Cl3N4OS
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Salubrinal sc-202332 1 mg $32.00
Salubrinal sc-202332A 5 mg $100.00

Salubrinal is a cell-permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Shown to protect cells from endoplasmic reticulum (ER) stress-induced apoptosis (EC50~15μM) in PC12 cell lines induced with the protein glycosylation inhibitor tunicamycin (sc-201539), and brefeldin A (sc-200861), which causes ER stress by blocking ER-to-Golgi vesicle transport. Salubrinal is a potentially useful agent to study mechanisms of ER stress-induced apoptosis.


References

1. Boyce, M., et al. 2005. Science. 307: 935-939. PMID: 15705855
2. Boyce, M., et al. 2008. Cell Death Differ. 15: 589-599. PMID: 18188169
3. Razi, M., et al. 2009. J. Cell Biol. 185: 305-321. PMID: 19364919

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (96 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (2 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
276.03° C (Predicted)
Boiling Point :
635.79° C (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.73 (Predicted)
IC50 :
HSV replication: IC50 = 3 µM; PC-12: IC50 = 15 µM (rat); Endoplasmic reticulum stress-induced apoptosis: IC50 = ~15 µM
pK Values :
pKa: 10.7 (Predicted), pKb: 2.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5717801
MDL Number :
MFCD00548612
SMILES :
C1=CC=C(C=C1)/C=C/C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC2=CC=CC3=C2N=CC=C3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

You May Also Like

SalubrinalProduct Citations

See how others have used Salubrinal. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 51 total

PMID: # 28276506
Dimasi, P. et al. 2017. Modulation of p-eIF2α cellular levels and stress granule assembly/disassembly by trehalose. Sci Rep. 7: 44088.

PMID: # 28300624
da Silva, DC. et al. 2017. Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum. J. Steroid Biochem. Mol. Biol.. 171: 178-186.

PMID: # 26939760
Song, Q. et al. 2016. FAM3A attenuates ER stress-induced mitochondrial dysfunction and apoptosis via CHOP-Wnt pathway. Neurochemistry international. 94: 82-9.

PMID: # 25409632
Ma, R. et al. 2016. HIV Tat-Mediated Induction of Human Brain Microvascular Endothelial Cell Apoptosis Involves Endoplasmic Reticulum Stress and Mitochondrial Dysfunction. Molecular neurobiology. 53: 132-42.

PMID: # 26938301
Datan, E. et al. 2016. Dengue-induced autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation Cell Death and Disease. 7: 10.

PMID: # 26144282
Maranto, C. et al. 2015. Cellular stress induces cap-independent alpha-enolase/MBP-1 translation. FEBS letters. 589: 2110-6.

PMID: # 25164368
Park, M. et al. 2015. Palmitate induces ER stress and autophagy in H9c2 cells: implications for apoptosis and adiponectin resistance. Journal of cellular physiology. 230: 630-9.

PMID: # 25354317
Zeng, LX. et al. 2015. β-Arrestin2 encourages inflammation-induced epithelial apoptosis through ER stress/PUMA in colitis. Mucosal immunology. 8: 683-95.

PMID: # 26078563
Lee, IK. et al. 2015. Induction of endoplasmic reticulum-derived oxidative stress by an occult infection related S surface antigen variant. World J. Gastroenterol.. 21: 6872-83.

PMID: # 25634760
Tang, X. et al. 2015. Advanced oxidation protein products induce hypertrophy and epithelial-to-mesenchymal transition in human proximal tubular cells through induction of endoplasmic reticulum stress. Cell. Physiol. Biochem.. 35: 816-28.

Citations 1 to 10 of 51 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 161ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from We used this several times in our lab and We used this several times in our lab and got good results.
Date published: 2015-08-26
Rated 5 out of 5 by from K K-562 cells were treated with with both lambda protein phosphatase and Salubrinal, followed by WB analysis. The presence of Salubrinal has prevented lambda protein phosphatase from de-phosphorylating p-Cofilin 1. -SCBT QC
Date published: 2015-02-10
  • y_2018, m_5, d_25, h_1
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.8
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_en_US, sid_202332, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 62ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.