Salinomycin is a polyether potassium ionophore antibiotic, which promotes cation movement across biological membranes via exchange-diffusion. As a result of this cation exchange, the transmembrane gradients are altered, which leads to changes in cellular function and metabolism. In addition, Salinomycin acts as a chelating agent towards monovalent cations such as sodium and potassium ions. Alternate studies suggest that Salinomycin selectively inhibits cancer stem-like cells.
1. Dong, T.T., et al. 2011. Ann Surg Oncol. [Epub ahead of print]. PMID: 21267784 2. Wang, Y. 2011. Med Chem. [Epub ahead of print]. PMID: 21222617
Solubility: Soluble in methanol (10 mg/mL)
Store at -20° C
~839.2° C at 760 mmHg (Predicted)
~1.2 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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