Salinomycin A polyether potassium ionophore antibiotic, which promotes cation movement across biological membranes via exchange-diffusion.

Salinomycin  (CAS 53003-10-4)

Salinomycin is rated 4.0 out of 5 by 1.
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Application: A polyether potassium ionophore
CAS Number: 53003-10-4
Purity: ≥98%
Molecular Weight: 751.00
Molecular Formula: C42H70O11
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Salinomycin sc-253530 5 mg $150.00
Salinomycin sc-253530A 25 mg $510.00

Salinomycin is a polyether potassium ionophore antibiotic, which promotes cation movement across biological membranes via exchange-diffusion. As a result of this cation exchange, the transmembrane gradients are altered, which leads to changes in cellular function and metabolism. In addition, Salinomycin acts as a chelating agent towards monovalent cations such as sodium and potassium ions. Alternate studies suggest that Salinomycin selectively inhibits cancer stem-like cells.


References

1. Dong, T.T., et al. 2011. Ann Surg Oncol. [Epub ahead of print]. PMID: 21267784
2. Wang, Y. 2011. Med Chem. [Epub ahead of print]. PMID: 21222617

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Solubility: Soluble in methanol (10 mg/mL)
Storage :
Store at -20° C
Melting Point :
112.5-113.5 lit
Boiling Point :
~839.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 3462, Class 6.1, Packing group II
PubChem CID :
72370
MDL Number :
MFCD00865281
EC Number :
258-290-1
SMILES :
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O

Download SDS (MSDS)

Certificate of Analysis

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Date published: 2015-04-20
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