S(-)-Cyanopindolol hemifumarate salt A 5-HT1A/1B serotonin receptor & β-adrenoceptor antagonist

S(-)-Cyanopindolol hemifumarate salt (CAS 874882-72-1)

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Synonym: 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carbonitrile hemifumarate salt
Application: A 5-HT1A/1B serotonin receptor & β-adrenoceptor antagonist
CAS Number: 874882-72-1
Molecular Weight: 345.39
Molecular Formula: C32H42N6O40.5C4H4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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S(-)-Cyanopindolol hemifumarate salt is a 5-HT1A/1B serotonin receptor antagonist; β3-adrenoceptor antagonist.


References

Hoey, A.J., et al., Characteristics of cyanopindolol analogues active at the beta 3-adrenoceptor in rat ileum. Br. J. Pharmacol. 119, 564-568, (1996) Pauwels, P.J., and Palmier, C., Differential functional activity of 5-hydroxytryptamine receptor ligands and beta adrenergic receptor antagonists and 5-hydroxytryptamine1B receptor sites in Chinese hamster lung fibroblasts and opossum renal epithelial cells. J. Pharmacol. Exp. Ther. 270, 938-945, (1994) Giles, H., Characterization of a 5-HT1B receptor on CHO cells: Functional responses in the absence of radioligand binding. Br. J. Pharmacol. 117, 1119-1126, (1996)

Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL
Storage :
Store at room temperature
Melting Point :
252-253° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16219075
SMILES :
CC(C)(C)NC[C@H](CC1=C2C=C(NC2=CC=C1)C#N)O.CC(C)(C)NC[C@H](CC1=C2C=C(NC2=CC=C1)C#N)O.C(=C/C(=O)O)\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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