Rufloxacin HydrochlorideA fluoroquinolone antibacterial

Rufloxacin Hydrochloride (CAS 106017-08-7)

Rufloxacin Hydrochloride | CAS 106017-08-7 is rated 5.0 out of 5 by 1.
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Synonym: Qari; Tebraxin; MF-934 hydrochloride
Application: A fluoroquinolone antibacterial
CAS Number: 106017-08-7
Purity: ≥98%
Molecular Weight: 399.87
Molecular Formula: C17H18FN3O3S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rufloxacin hydrochloride is a fluoroquinolone antibacterial that shows photosensitizing properties toward biological substrates. It inhibits B-cell differentiation in human mononuclear cells. Rufloxacin Hydrochloride is an inhibitor of Topo.


References

1. Cecchetti, V., et al. 1987. J. Med. Chem. 30: 465-473. PMID: 3820216
2. Wise, R., et al. 1992. J. Antimicrob. Chemother. 29: 649-660. PMID: 1324239
3. Gollapudi, S., et al. 1992. J. Antimicrob. Chemother. 29: 669-676. PMID: 1324240
4. Kisicki, J.C., et al. 1992. Antimicrob. Agents Chemother. 36: 1296-1301. PMID: 1329618
5. Klietmann, W., et al. 1993. Antimicrob. Agents Chemother. 37: 2298-2306. PMID: 8285609
6. Mattina, R., et al. 1993. Infection 21: 106-111. PMID: 8387963
7. Piddock, L.J., et al. 1993. J. Antimicrob. Chemother. 31: 855-863. PMID: 8395493
8. Condorelli, G., et al. 1999. Photochem. Photobiol. 70: 280-286. PMID: 10483356
9. Moretti,. M.V., et al. 2000. Antimicrob. Agents Chemother. 44: 73-77. PMID: 10602726
10. Catalfo, A., et al. 2007. Photochem. Photobiol. Sci. 6: 181-189. PMID: 17277842

Physical State :
Solid
Solubility :
Soluble in water, and methanol (very slightly). Insoluble in chloroform (almost), and acetic acid (almost).
Storage :
Store at -20° C
Boiling Point :
574.6° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.72
IC50 :
PhoP regulon: IC50 = 3.26 µM (Salmonella typhi); PhoP regulon: EC5050 >50 µM (Salmonella typhi)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
176015
Merck Index :
14: 8294
SMILES :
Cl.CN1CCN(CC1)C1=C2SCCN3C=C(C(O)=O)C(=O)C(C=C1F)=C23

Download SDS (MSDS)

Certificate of Analysis

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Rufloxacin Hydrochloride  Product Citations

See how others have used Rufloxacin Hydrochloride. Click on the entry to view the PubMed entry .

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PMID: # 2024974  Imbimbo, BP. et al. 1991. Antimicrob. Agents Chemother. 35: 390-393.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Imbimbo et al Imbimbo et al. (PubMed ID 2024974) found Rufloxacin Hydrochloride, an antibacterial agent, had a long half-life in plasma after a single dose due to its high plasma protein binding capabilities -SCBT Publication Review
Date published: 2015-03-28
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