(RS)-MCPG disodium saltA non-selective group I/II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt (CAS 1303994-09-3)

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Synonym: (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Application: A non-selective group I/II metabotropic glutamate receptor antagonist
CAS Number: 1303994-09-3
Purity: ≥99%
Molecular Weight: 253.16
Molecular Formula: C10H9NO42Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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(RS)-MCPG disodium salt is a a non-selective group I/group II metabotropic glutamate receptor antagonist. Metabotropic glutamate receptors (mGluR) are divided into group I, group II, and group III. Group I receptors are coupled to Gq/11 and are activators of phospholipase C. Group II and group III receptors are coupled to Gi/0 which in turn inhibits adenylyl cyclase, decreasing the formation of cAMP.


References

1. Eaton, S.A., et al. 1993. Eur. J. Pharmacol. 244: 195-197. PMID: 8381746
2. Watkins, J., et al. 1994. Trends Pharmacol Sci. 5: 333-342. PMID: 7992387
3. Joly, C., et al. 1995. J. Neurosci. 15: 3970-3981. PMID: 7751958

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at room temperature
Refractive Index :
n20D ~1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
MDL Number :
MFCD18086886

Download SDS (MSDS)

Certificate of Analysis

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