Royal Jelly acid is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. Royal Jelly and Chinese red propolis suppressed both VEGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration. Royal jelly has been reported as a possible immunomodulatory agent in Graves' disease. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain. To date, there is preliminary evidence that it may have some cholesterol-lowering, antiinflammatory, wound-healing, and antibiotic effects, though the last three of these effects are unlikely to be realized if ingested (due to the destruction of the substances involved through digestion, or neutralization via changes in pH). Research also suggests that the 10-Hydroxy-2-decenoic acid (10-HDA) found in royal jelly may inhibit the vascularization of tumors.
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