Royal Jelly acid An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation

Royal Jelly acid (CAS 14113-05-4)

Royal Jelly acid | CAS 14113-05-4 is rated 5.0 out of 5 by 1.
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Synonym: (E)-10-Hydroxy-2-Decenoic Acid
Application: An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation
CAS Number: 14113-05-4
Purity: ≥98%
Molecular Weight: 186.25
Molecular Formula: C10H18O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Royal Jelly acid is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. Royal Jelly and Chinese red propolis suppressed both VEGF-induced human umbilical vein endothelial cells (HUVECs) proliferation and migration. Royal jelly has been reported as a possible immunomodulatory agent in Graves' disease. It has also been reported to stimulate the growth of glial cells and neural stem cells in the brain. To date, there is preliminary evidence that it may have some cholesterol-lowering, antiinflammatory, wound-healing, and antibiotic effects, though the last three of these effects are unlikely to be realized if ingested (due to the destruction of the substances involved through digestion, or neutralization via changes in pH). Research also suggests that the 10-Hydroxy-2-decenoic acid (10-HDA) found in royal jelly may inhibit the vascularization of tumors.

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), methanol (~30 mg/ml), DMF (~30 mg/ml), and chloroform.
Storage :
Store at -20° C
Melting Point :
63-65° C
Boiling Point :
~339.2° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5312738
MDL Number :
MFCD00204506
SMILES :
C(CCC/C=C/C(=O)O)CCCO

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Certificate of Analysis

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Rated 5 out of 5 by from Karaca Karaca, T. et al. (PubMed 26019800) reported that Royal Jelly acid exhibited protective effects in 2,4,6 trinitrobenzene sulfonic acid-induced colitis in rats. -SCBT Publication Review
Date published: 2015-04-22
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