Rosuvastatin Calcium Salt A selective, competitive inhibitor of HMG-CoA reductase, that is also antilipemic.

Rosuvastatin Calcium Salt  (CAS 147098-20-2)

Rosuvastatin Calcium Salt is rated 5.0 out of 5 by 1.
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| See 3 Citations
Synonym: (3R,5S,6E)-
Application: A selective and competitive inhibitor of HMG-CoA reductase
CAS Number: 147098-20-2
Purity: ≥99%
Molecular Weight: 1001.14
Molecular Formula: C44H54F2N6O12S2•Ca
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
Rosuvastatin Calcium Salt sc-208316 10 mg $126.00

Rosuvastatin Calcium Salt is a selective, competitive inhibitor of HMGCR (HMG-CoA reductase), that is also antilipemic.


References

Watanabe, M., et al.: Bioorg. Med. Chem., 5, 437 (1997), Lee, E., et al.: Clin. Pharmacol. Ther., 78, 330 (2005), Ferdinand, K.C., et al.: Am. J. Cardiol., 97, 229 (2006),

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (< 1 mg/ml at 25° C), chloroform, DMSO (100 mg/ml at 25° C), methanol, and ethanol (< 1 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
151-156° C
Refractive Index :
n20D 1.60 (Predicted)
Optical Activity :
α20/D +6.8º, c = 1 in methanol; α20/D -9.9º, c = 1 in chloroform; α20/D +14.8º, c = 1.012 in 50% MeOH
IC50 :
HMG-CoA reductase: IC50 = 2.1 nM (rat); HMGCRHMGCRHMGCR: IC50 = 3.1 nM (human); Liver microsomes: IC50 = 3.6 nM (rat); L6: IC50 = 65 nM (rat); Plasmodium falciparum: IC50 = 80 µM
Ki Data :
HMGCRHMGCRHMGCR: Ki= 0.9 (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
MJ9675070
PubChem CID :
6436658
MDL Number :
MFCD04112702
SMILES :
CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]

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Certificate of Analysis

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Rosuvastatin Calcium Salt Product Citations

See how others have used Rosuvastatin Calcium Salt. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25929522
Vrzal, R. et al. 2015. The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes. Toxicology in vitro : an international journal published in association with BIBRA. 29: 1088-99.

PMID: # 25565957
Kilic, E. et al. 2014. HMG-CoA Reductase Inhibition Promotes Neurological Recovery, Peri-Lesional Tissue Remodeling, and Contralesional Pyramidal Tract Plasticity after Focal Cerebral Ischemia. Frontiers in cellular neuroscience. 8: 422.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Chiang Chiang, KH. et al. (PubMed 26309120) analyzed the effects of Rosuvastatin Calcium Salt, a selective, competitive inhibitor of HMG-CoA reductase, treatments in recovery of capillary density and blood flow, the expression of vWF and CXCR4 at ischemia sites in hindlimb ischemia ICR mice. The results indicated that Rosuvastatin treatment led to significantly more CXCR4-positive endothelial progenitor cells incorporated into ischemic sites and in the blood compared with control mice. -SCBT Publication Review
Date published: 2015-04-12
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