Ro 60-0175 fumarateA potent and selective SR-2 agonist

Ro 60-0175 fumarate (CAS 169675-09-6)

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Synonym: (aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate
Application: A potent and selective SR-2 agonist
CAS Number: 169675-09-6
Purity: ≥98%
Molecular Weight: 342.75
Molecular Formula: C11H12ClFN2 C4H4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ro 60-0175 fumarate is a potent, selective SR-2 agonist. Ro 60-0175 shows selectivity for the SR-2C subtype.


References

Martin et al (1998) 5-HT2C receptor agonists: pharmacological characteristics and therapeutic potential. J.Pharmacol.Exp.Ther. 286 913. Kennett et al (2000) Effects of Ro 60 0175, a 5-HT2C receptor agonist, in three animal models of anxiety. Eur.J.Pharmacol. 387 197. Damjanoska et al (2003) Neuroendocrine evidence that (S)-2-(chloro-5-fluoro-indol-l-yl)-1-methylethylamine fumarate (Ro 60-0175) is not a selective 5-hydroxytryptamine2C receptor agonist. J.Pharmacol.Exp.Ther. 304 1209.

Physical State :
Solid
Solubility :
Soluble to 5 mM in Water
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6446435
SMILES :
C[C@@H](CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=C/C(=O)O)\\C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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