RO-3306 RO-3306 is shown to be an inhibitor of CDK1/cyclin B1 and CDK1/cyclin A. RO-3306 allows for effective cell synchronisation in early mitosis.

RO-3306  (CAS 872573-93-8)

RO-3306 is rated 5.0 out of 5 by 1.
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| See 10 Citations
Synonym: 5-(quinolin-6-ylmethylidene)-2-(thiophen-2-ylmethylamino)-1,3-thiazol-4-one
Application: An inhibitor of CDK1/cyclin B1 and CDK1/cyclin A
CAS Number: 872573-93-8
Purity: ≥95%
Molecular Weight: 351.44
Molecular Formula: C18H13N3OS2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ordering Information

PRODUCT NAME CATALOG # UNIT PRICE QTY FAVORITES
RO-3306 sc-358700 1 mg $55.00
RO-3306 sc-358700A 5 mg $150.00

RO-3306 has been shown to inhibit CDK1/cyclin B1 and CDK1/cyclin A. RO-3306 reversibly arrests human cells at the G2/M border of the cell cycle. RO-3306 allows for effective cell synchronization in early mitosis.

Physical State :
Solid
Solubility :
DMSO (5mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71433937
SMILES :
C1=CC2=C(C=CC(=C2)C=C3C(=O)N=C(S3)NCC4=CC=CS4)N=C1

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RO-3306 Product Citations

See how others have used RO-3306. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26923777
Wong, PY. et al. 2016. MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Sci Rep. 6: 22230.

PMID: # 26188358
Zhou, W. et al. 2015. Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells. Oncotarget. 6: 21557-71.

PMID: # 26304237
Ye, XS. et al. 2015. A Novel Eg5 Inhibitor (LY2523355) Causes Mitotic Arrest and Apoptosis in Cancer Cells and Shows Potent Antitumor Activity in Xenograft Tumor Models. Mol. Cancer Ther.. 14: 2463-72.

PMID: # 24996901
Kotak, S. et al. 2014. NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane. EMBO J.. 33: 1815-30.

PMID: # 25048371
Häfner, J. et al. 2014. Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nat Commun. 5: 4397.

PMID: # 25130574
Tuvshintugs, B. et al. 2014. JSAP1 and JLP are required for ARF6 localization to the midbody in cytokinesis. Genes Cells. 19: 692-703.

PMID: # 24100295
Listovsky, T. et al. 2013. Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset. J. Cell Biol.. 203: 87-100.

PMID: # 23921553
Kotak, S. et al. 2013. NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function. EMBO Journal. 18: 1-13.

PMID: # 24189531
Warfel, NA. et al. 2013. CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth. Cell Cycle. 12: 3689-701.

PMID: # 23936128
Brown, et al. 2013. Cep63 and Cep152 Cooperate to Ensure Centriole Duplication PLoS One. 8:

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Czaplinski et al Czaplinski et al. (PubMed ID 26046302) used RO-3306 to ininhibit CDK1 to decrease cell death by interfering with mitotic arrest and preventing the phosphorylation of BCl-2 and BCL-XL along with MCL-1 downregulation. -SCBT Publication Review
Date published: 2015-04-20
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