Ro 08-2750 A TrkA inhibitor and NGF-induced apoptosis inhibitor

Ro 08-2750 (CAS 37854-59-4)

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Synonym: 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Application: A TrkA inhibitor and NGF-induced apoptosis inhibitor
CAS Number: 37854-59-4
Molecular Weight: 270.24
Molecular Formula: C13H10N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ro 08-2750 is an inhibitor of NGF-induced apoptosis. At submicromolar concentrations, Ro 08-2750 inhibits binding selectively to p75NTR. At higher concentrations, Ro 08-2750 inhibits binding selectively to P75NTR and TrkA. In SK-N-MC cells, it prevents NGF-induced apoptosis. Ro 08-2750 is an inhibitor of NGFR.


References

1. Niederhauser, O., et al. 2000. J. Neurosci. Res. 61: 263-272.
2. Arkin, M.R. and Wells, J.A. 2004. Nat. Rev Drug Discov. 3: 301-317.

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (50 mM), and DMSO (10 mM).
Storage :
Store at -20° C
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
NGF: IC50 = 1 µM (human)
pK Values :
pKa: 9.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
17756791
MDL Number :
MFCD09038552
SMILES :
CC1=CC2=C(C=C1C=O)N(C3=NC(=O)NC(=O)C3=N2)C

Download SDS (MSDS)

Certificate of Analysis

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