Rifaximin An antibiotic that inhibits RNA synthesis and activates PXR

Rifaximin (CAS 80621-81-4)

Rifaximin | CAS 80621-81-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_5, d_23, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_205841, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 234ms
  • REVIEWS, PRODUCT
Synonym: 4-Deoxy-4′-methylpyrido[1′,2′-1,2]imidazo[5,4-c]rifamycin SV, Rifacol
Application: An antibiotic that inhibits RNA synthesis and activates PXR
CAS Number: 80621-81-4
Purity: ≥99%
Molecular Weight: 785.88
Molecular Formula: C43H51N3O11
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Rifaximin is an antibiotic that inhibits RNA synthesis and acts as a PXR (pregnane-X-receptor) activator. The compound is a derivative of rifamycin that has been shown to act strongly against Enterococcus, Streptococcus and Staphylococcus, with less activity against Enterobacteriaceae. Rifaximin has been used in a variety of gastrointestinal and intestinal epithelial cell studies.


References

1. Gillis, J.C. and Brogden, R.N. 1995. Drugs. 49: 467-484. PMID: 7774516
2. Mencarelli, A., et al. 2010. Biochem Pharmacol. [Epub ahead of print]. PMID: 20816942
3. Cottreau, J., et al. 2010. Expert Rev Anti Infect Ther. 8: 747-760. PMID: 20586560
4. Cheng, J., et al. 2010. J. Pharmacol. Exp. Ther. 335: 32-41. PMID: 20627999

Physical State :
Solid
Solubility :
Soluble in DMSO (47 mg/ml), water (<1 mg/ml), ethanol (157 mg/ml), alcohols, and chloroform.
Storage :
Store at 4° C
Melting Point :
218-228° C
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Staphylococcus epidermidis RNA polymerase mediated transcription: IC50 = 89.07 nM; PXR: EC5050 = 2.2 µM (human)
pK Values :
pKa: 8.06 (Predicted), pKb: 4.42 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
KD1576000
PubChem CID :
6436173
Merck Index :
14: 8220
MDL Number :
MFCD00864973
SMILES :
C[C@H]1/C=C/C=C(\\C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)O[C@@](C4=O)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)/C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 65ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Cheng et al Cheng et al. (PubMed ID 20627999) found that rifaximin showed a therapeutic effect against inflammatory bowel disease via human PXR-mediated inhibition of the NF- B signaling cascade. -SCBT Publication Review
Date published: 2015-03-09
  • y_2019, m_5, d_23, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_205841, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 147ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.