Rifaximin is an antibiotic that inhibits RNA synthesis and acts as a PXR (pregnane-X-receptor) activator. The compound is a derivative of rifamycin that has been shown to act strongly against Enterococcus, Streptococcus and Staphylococcus, with less activity against Enterobacteriaceae. Rifaximin has been used in a variety of gastrointestinal and intestinal epithelial cell studies.
1. Gillis, J.C. and Brogden, R.N. 1995. Drugs. 49: 467-484. PMID: 7774516 2. Mencarelli, A., et al. 2010. Biochem Pharmacol. [Epub ahead of print]. PMID: 20816942 3. Cottreau, J., et al. 2010. Expert Rev Anti Infect Ther. 8: 747-760. PMID: 20586560 4. Cheng, J., et al. 2010. J. Pharmacol. Exp. Ther. 335: 32-41. PMID: 20627999
Soluble in DMSO (47 mg/ml), water (<1 mg/ml), ethanol (157 mg/ml), alcohols, and chloroform.
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Cheng et alCheng et al. (PubMed ID 20627999) found that rifaximin showed a therapeutic effect against inflammatory bowel disease via human PXR-mediated inhibition of the NF- B signaling cascade. -SCBT Publication Review
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