Rifamycin SV monosodium salt An antimicrobial agent which inhibits DNA polymerase

Rifamycin SV monosodium salt (CAS 14897-39-3)

Rifamycin SV monosodium salt | CAS 14897-39-3 is rated 5.0 out of 5 by 1.
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Synonym: Rifocin; Rifamastene
Application: An antimicrobial agent which inhibits DNA polymerase
CAS Number: 14897-39-3
Molecular Weight: 719.75
Molecular Formula: C37H46NO12 Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rifamycin SV monosodium salt is an antimicrobial agent which inhibits DNA polymerase. Rifamycin SV monosodium salt is an inhibitor of RNA Polymerase.


References

Furesz S, Arioli V, Pallanza R. Antimicrob Agents Chemother. 5:770-7 (1965). Frolova LY, Meldrays YA, Kochkina LL et al. Nucleic Acids Res. 4:523-38 (1977).

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml, Clear to slightly hazy red to very deep red), DMSO, and water(pH7.2), and methanol.
Storage :
Store at -20° C
Melting Point :
>215° C (dec.)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
BSEP: IC50 = 12.2 µM (human)
Ki Data :
OATP-C: Ki= 2 µM (human); OATP-B: Ki= 3 µM (human); OATP8: Ki= 3 µM (human); Bile salt export pump: Ki= 3.8 µM (rat); Solute carrier organic anion transporter family member 1A1: Ki= 6.6 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
KD1922500
PubChem CID :
23702994
Merck Index :
14: 8218
MDL Number :
MFCD00056847
EC Number :
238-965-7
SMILES :
C[C@H]1/C=C/C=C(\C(=O)NC2=CC(=C3C(=C2O)C(=C(C4=C3C(=O)[C@](O4)(O/C=C/[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]1O)C)O)C)OC(=O)C)C)OC)C)C)O)[O-])/C.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications cite the use of Rifamycin Various publications cite the use of Rifamycin SV monosodium salt due to its ability to inhibit both DNA and RNA polymerase. -SCBT Publication Review
Date published: 2015-05-03
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