Ribavirin A broad spectrum antiviral nucleoside and inhibitor of inosine monophosphate dehydrogenase

Ribavirin (CAS 36791-04-5)

Ribavirin | CAS 36791-04-5 is rated 5.0 out of 5 by 1.
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Synonym: 1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Application: A broad spectrum antiviral nucleoside and inhibitor of inosine monophosphate dehydrogenase
CAS Number: 36791-04-5
Purity: >98%
Molecular Weight: 244.20
Molecular Formula: C8H12N4O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ribavirin is a non-interferon-inducing, broad spectrum antiviral nucleoside. Ribavirin is reported to be active against RSV, HIV, HCV, and other infectious agents. The compound's metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.


References

Li, W., et al. 1999. Oncol. Res. 11, 243. Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653. Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285. Kakumu, S., et al. 1993. Gastroenterology 105, 507. Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123. R: 61; S: 3/7/9-22-45-53

Usage :
Reconstituted solutions should be prepared immediately before use or may be stored at 2 to 6°C up to 24 hours.
Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml), DMSO (49 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), and alcohol (slightly).
Storage :
Store at 4° C
Melting Point :
173° C (lit.)
Boiling Point :
639.78° C at 760 mmHg (Predicted)
Density :
2.09 g/cm3 (Predicted)
Refractive Index :
n20D 1.82 (Predicted)
Optical Activity :
α20/D -38°±3°, c = 1 in water
IC50 :
colony formation of primary AML-M5 progenitor cells: IC50 = ~1 µM; IMPDH: IC50 = 1 µM (mouse); IMPDH: IC50 = 1 µM (human); Influenza A virus: IC50 = 1.9 µM; growth of ovarian carcinoma OVCAR-5 cells: IC50 = 35 µM; growth of human myeloma 8226 cells: IC50 = 40 µM
Ki Data :
active metabolite, ribavirin triphosphate: Ki= ~0.3 µM
pK Values :
pKa: 12.95 (Predicted), pKb: 0.21 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XZ4250000
PubChem CID :
37542
Merck Index :
14: 8198
MDL Number :
MFCD00058564
Beilstein Registry :
892462
SMILES :
C1=NC(=NN1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)C(=O)N

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Ribavirin  Product Citations

See how others have used Ribavirin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 22978816  Huang, S. et al. 2012. Anal. Chem. 84: 8118-21.

Citations 1 to 1 of 1 total

Hi, How can I solve the powdered ribavirin &ge; 98% pure? thanks

Asked by: Elaheh
Thank you for your question. Ribavirin (CAS 36791-04-5) sc-203238 is soluble in water (20 mg/ml), DMSO (49 mg/ml at 25&deg; C), ethanol (&lt;1 mg/ml at 25&deg; C), and alcohol (slightly). For further information please contact our technical service team.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-29
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Rated 5 out of 5 by from Shi Shi, F. et al. (PubMed 26317515) found that Ribavirin, a broad spectrum antiviral nucleoside, inhibits the activity of mTOR/eIF4E, ERK/Mnk1/eIF4E signaling pathway and synergizes with tyrosine kinase inhibitor Imatinib to impair Bcr-Abl mediated proliferation and apoptosis in Ph+ leukemia. -SCBT Publication Review
Date published: 2015-01-05
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