Rho Kinase Inhibitor A cell-permeable isoquinolinesulfonamide compound

Rho Kinase Inhibitor

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Synonym: ROCK Inhibitor
Application: A cell-permeable isoquinolinesulfonamide compound
Purity: ≥95%
Molecular Weight: 392.34
Molecular Formula: C16H21N3O2S 2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Rho Kinase Inhibitor is a cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, potent, and ATP-competitive inhibitor of ROCK (G-protein Rho-associated kinase). The compound exhibits a much weaker affinity for other serine/threonine kinases. Rho Kinase Inhibitor has been shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS in NT-2 cells.


References

Ikenoya, M., et al. 2002. J. Neurochem. 81, 9. Sasaki, Y., et al. 2002. Pharmacol. Ther. 93, 225.

Physical State :
Solid
Solubility :
Soluble in water, and methanol.
Storage :
Store at 4° C
Boiling Point :
562.6° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.59 (Predicted)
IC50 :
lysophosphatidic acid-induced phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS: IC50 = 2.5 µM (NT-2 cells)
Ki Data :
ROCK: Ki= 1.6 nM; PKA: Ki= 630 nM; PKC: Ki= 9.27 µM; MLCK: Ki= 10.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11560225
SMILES :
C[C@H]1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)C.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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