RGD peptide (GRGDNP) An inhibitor of integrin-ligand interactions

RGD peptide (GRGDNP) (CAS 114681-65-1)

RGD peptide (GRGDNP) | CAS 114681-65-1 is rated 5.0 out of 5 by 1.
  • y_2019, m_4, d_23, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201176, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 99ms
  • REVIEWS, PRODUCT
Application: An inhibitor of integrin-ligand interactions
CAS Number: 114681-65-1
Purity: ≥97%
Molecular Weight: 614.61
Molecular Formula: C23H38N10O10
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

RGD peptide (GRGDNP) acts as an inhibitor of integrin-ligand interactions and can induce apoptosis in the absence of signals and integrin-mediated cell clustering. Research demonstrates that RGD peptides promote apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. The RGD peptide can serve as a cell adhesion site of extracellular matrix, cell surface proteins, and integrins. In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion.


References

1. Ruoslahti, E. 1996. Annu. Rev. Cell Dev. Biol. 12: 697-715. PMID: 8970741
2. Meredith, J.E. and Schwartz, M.A. 1997. Trends Cell Biol. 7: 146-150. PMID: 17708932
3. Yang, W., et al. 1999. J. Biol. Chem. 274: 8524-8530. PMID: 10085085
4. Buckley, C.D., et al. 1999. Nature. 397: 534-539. PMID: 10028971

Physical State :
Solid
Sequence :
Gly-Arg-Gly-Asp-Asn-Pro
Solubility :
Soluble in water (>50 mg/ml)
Storage :
Store at -20° C
Density :
~1.7 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9895205
SMILES :
C1C[C@H](N(C1)C(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)CN)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

RGD peptide (GRGDNP)  Product Citations

See how others have used RGD peptide (GRGDNP). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 25415317  Carrim, N. et al. 2014. PloS one. 9: e113679.

PMID: # 24843046  Marbiah, MM. et al. 2014. The EMBO journal. 33: 1527-47.

PMID: # 24768768  Gao, M. et al. 2014. Cellular signalling. 26: 2161-6.

PMID: # 24785587  Lee, SH. et al. 2014. Radiat. Res. 181: 650-8.

PMID: # 23331249  Chang, IA. et al. 2013. Journal of neurochemistry. 125: 214-24.

PMID: # 23145974  Hillman, RD. et al. 2013. Cell. Microbiol. 15: 727-41.

PMID: # 7983003  Qwarnstrom, E.E. et al. 1994. J. Biol. Chem. 269: 30765-30768.

Citations 1 to 7 of 7 total

Can this RGD inhibit a1a1 integrin?

Asked by: stace1234
We are not able to provide this information at this time. Here is some literature that may be helpful: PubMedID: 26309781 PubMedID: 9294134
Answered by: Technical Support
Date published: 2018-12-14

can this RGD inhibit a1b1 integrin?

Asked by: stace1234
We are not able to provide this information at this time. Here is some literature that may be helpful: PubMedID: 26309781 PubMedID: 9294134
Answered by: Technical Support
Date published: 2018-12-14

Do you have RGD peptides with maleimide attached?

Asked by: ccchen777
Thank you for your question. We do not currently offer this product with maleimide attached.
Answered by: Technical Support
Date published: 2017-03-22

Have you examined the solubility of RGD peptide in DMSO or buffered solutions like PBS? Or in the presence of cryoprotectants like the addition of DTT, sucrose or glycerol?

Asked by: 13punMA
Thank you for asking about our product RGD peptide (GRGDNP) (CAS# 114681-65-1) Besides water, we have not experimented the solubility of the RGD peptide with any other organic solvents. Nevertheless, from our experience, DMSO brings (almost all) peptides into solution rather quickly, so we suspect that it should work for this short peptide as well.
Answered by: Chemical Support 8
Date published: 2017-03-10
  • y_2019, m_4, d_23, h_2CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_4
  • loc_en_US, sid_201176, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 87ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Qwarnstrom et al Qwarnstrom et al. (PubMed ID 7983003) found RGD peptide (GRGDNP) increased attachment-dependent activity in the fibronectin binding sites of fibroblasts and smooth muscle cells. -SCBT Publication Review
Date published: 2015-05-30
  • y_2019, m_4, d_23, h_2
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.12
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201176, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.