Resveratrol A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1

Resveratrol (CAS 501-36-0)

Resveratrol | CAS 501-36-0 is rated 4.5 out of 5 by 2.
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Synonym: Trans-3,4',5-Trihydroxystilbene; 1,3-Benzenediol, 5-[2-(4-hydroxyphenyl)ethenyl]-
Application: A natural phenolic antioxidant that is a potent activator of SIRT1 and inhibitor of Cox-1
CAS Number: 501-36-0
Purity: ≥98%
Molecular Weight: 228.24
Molecular Formula: C14H12O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural polyphenol derived from red wine; in Asian folk-medicine it and it's glycoside, polydatin (sc-203203) are the primary ingredients of Kojo-Kon (derived from the dried root of Japanese knotweed). This trihydroxystilbene is derived from various sources and has been studied with regard to numerous applications including reducing serum lipids, inhibition of platelet aggregation, and actions as a chemopreventative agent and antioxidant. Resveratrol has been shown to increase the longevity of yeast and to display antiproliferative effects on cancer stem cells in vitro. Resveratrol is a specific inhibitor of Cox-1 (cyclooxygenase-1) via inhibition of the hydroperoxidase activity of Cox-1.

Resveratrol has also been used extensively in stem cell studies to enhance self-renewal and multipotency of mesencymal stem cells (MSC's) in vitro. Numerous studies have been conducted with regard to resveratrol-modified cardiac stem cells enhancing cardiac healing in vitro. Similar studies with bone marrow derived stem cells (BMSCs) have shown that resveratrol acts as a NF-κB inhibitor to protect MSC-derived chondrocytes in vitro. Additional research with resveratrol used to treat adipose-derived mesenchymal stem cells (ADMSCs) resulted in increased alkaline phosphatase activity and osteocalcin levels; thus enriching the MSC and osteoprogenitor cell populations in cultured ADMSCs in vitro.


References

1. Chanvitayapongs, S., et al. 1997. Neuroreport. 8: 1499-1502. PMID: 9172162
2. Gehm, B.D., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 14138-14143. PMID: 9391166
3. Fontecave, M., et al. 1998. FEBS Lett. 421: 277-279. PMID: 9468322
4. Srivastava, P., et al. 1998. Int. J. Oncol. 13: 465-469. PMID: 9683780
5. Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun. 262: 20-24. PMID: 10448061
6. Bowers, J.L., et al. 2000. Endocrinology. 141: 3657-3667. PMID: 11014220
7. Frémont, L., 2000. Life Sci. 66: 663-673. PMID: 10680575
8. Kimura, Y., 2003. Methods Find Exp Clin Pharmacol. 25: 297-310. PMID: 12808475
9. Howitz, K.T., et al. 2003. Nature. 425: 191-196. PMID: 12939617
10. Baur, J.A. and Sinclair, D.A. 2006. Nat Rev Drug Discov. 5: 493-506. PMID: 16732220
11. Lei, M., et al. 2008. Acta Pharmacol. Sin. 29: 1350-1356. PMID: 18954530
12. Pandey, P.R., et al. 2010. Breast Cancer Res Treat. PMID: 21188630
13. Gurusamy, N., et al. 2010. J. Cell. Mol. Med. 14: 2235-2239. PMID: 20716127
14. Kao, C.L., et al. 2010. Stem Cells Dev. 19: 247-258. PMID: 19656070

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (3 mg/100mL), ethanol (50 mg/mL), DMSO (≥16 mg/mL), DMF (~65 mg/mL), PBS (pH 7.2) (~100µg/mL), methanol, and acetone (50 mg/mL).
Storage :
Store at -20° C
Melting Point :
253-255° C
Boiling Point :
449.12° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
cytochrome P450 1A1: IC50 = 23 µM; PKD in vitro: IC50 = 200 µM; PKD in vivo: IC50 = 800 µM; Cytochrome P450 2C19: IC50 = 3 µM (human); HL-60 (Promyeloblast leukemia cells): IC50 = 36.3 µM (human); Cyclooxygenase-1: IC50 = 535 nM (Ovis aries); Monoamine oxidase A: IC50 = 449 nM (human)
pK Values :
pKa: 9.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CZ8987000
PubChem CID :
5056
Merck Index :
14: 8158
MDL Number :
MFCD00133799
EC Number :
610-504-8
Beilstein Registry :
1912434
SMILES :
C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Resveratrol  Product Citations

See how others have used Resveratrol. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 27771282  Kaur, M. et al. 2017. Brain Res. 1654: 9-23.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 28915620  Islam, SU. et al. 2017. Oncotarget. 8: 56659-56671.

PMID: # 27129153  Labay, E. et al. 2016. Oncotarget.

PMID: # 27634755  Allain, C. et al. 2016. Cancer Res. 76: 6374-6381.

PMID: # 26870238  Xiong, W. et al. 2016. Oncol Lett. 11: 484-490.

PMID: # 26158280  Kaur, M. et al. 2015. J Pharm Pharm Sci. 18: 132-54.

Kaur, et al. 2015. J Pharm Pharm Sci. 2: 132-154.

PMID: # 26246013  Yildiz, G. et al. 2015. Recent Pat Endocr Metab Immune Drug Discov. 9: 134-40.

PMID: # 26219912  Jung, YR. et al. 2015. Mol. Pharmacol. 88: 708-19.

Citations 1 to 10 of 13 total

Hello. What is the recommended shipping temperature for Resveratrol? What would be the estimated shipping charges to Miami, Fl? If shipping temperature is at room temperature how long will it last?

Asked by: Renato Castanho
Thank you for your question. This chemical is shipped domestically and internationally at ambient temperature. Please contact our Customer Care Department to request a shipping quote.
Answered by: Technical Support
Date published: 2018-12-06

Hi, for this resveratrol is pure trans-resveratrol? My experiment need use trans-resveratrol and cis-resveratrol differently. Do this resveratrol contain cis-resveratrol? Thanks.

Asked by: Ronni
Thank you for your question. The product that we offer, Resveratrol: sc-200808, is the trans isomer of Resveratrol and does not contain the cis isomer.
Answered by: Technical Support
Date published: 2017-05-17

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Resveratrol, sc-200808, is in white to off-white to light yellow powder.
Answered by: Chemical Support 4
Date published: 2017-04-06

Is this product sterile filtered?

Asked by: SCM4
Thank you for your question. Resveratrol, sc-200808, is not sterile filtered, though we welcome end-users to do it themselves.
Answered by: TechService7
Date published: 2018-03-13

Is sc-200808 HPLC grade?

Asked by: two2igm05
Thank you for your question. Resveratrol, sc-200808, is HPLC grade.
Answered by: TechService7
Date published: 2016-12-28

Was method was used to purify this product?

Asked by: SCM4
Resveratrol (CAS 501-36-0) was purified by HPLC.
Answered by: Tech Service 2
Date published: 2016-12-23
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Rated 5 out of 5 by from I used this in IPSC and works very well I used this in IPSC and works very well.
Date published: 2015-10-08
Rated 4 out of 5 by from I will rate this product a 4 and rate 5 I will rate this product a 4 and rate 5 for your logistics, customer service and support.
Date published: 2015-04-20
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