Razoxane An inhibitor of Topo II

Razoxane (CAS 21416-67-1)

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Synonym: (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); ICI 59118; ICRF 159; NSC 129943; Razoxin; Tepirone; Troxozone
Application: An inhibitor of Topo II
CAS Number: 21416-67-1
Molecular Weight: 268.27
Molecular Formula: C11H16N4O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Razoxane inhibits DNA topoisomerase II (Topo II) without inducing DNA strand breaks (topo II catalytic inhibitor).


References

Rhomberg W., et al., Combined vindesine and razoxane shows antimetastatic activity in advanced soft tissue sarcomas. Clin. Exp. Metastasis 25, 75-80, (2008) Rybak, S., et al., "Vasocrine" formation of tumor cell-lined vascular spaces: implications for rational design of antiangiogenic therapies. Cancer Res. 63, 2812-2819, (2003) Perret GY, Crépin M., New pharmacological strategies against metastatic spread. Fundam. Clin. Pharmacol. 22, 465-492, (2008)

Solubility :
Soluble in DMSO: 40 mg/mL
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
30623
SMILES :
CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2

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Certificate of Analysis

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