R5C3 An MDM2 inhibitor and probe for fluorescence polarization binding assay

R5C3 (CAS 753504-14-2)

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Synonym: 5-Methyl-N-(2-phenoxybenzoyl)-1-[(phenylmethoxy)carbonyl]-D/L-tryptophan
Application: An MDM2 inhibitor and probe for fluorescence polarization binding assay
CAS Number: 753504-14-2
Molecular Weight: 548.59
Molecular Formula: C33H28N2O6
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R5C3 is an MDM2 inhibitor, 2-phenoxybenzoyl-tryptophan derivative. It is reported as a novel probe for high throughput fluorescence polarization binding assay and is useful in screening for small molecule inhibitors of MDM2-binding to p53.


References

Zhang, R., et al., Fluroescence polarization assay and inhibitor design for MDM2/p53 interaction. Anal. Biochem. 331, 138-146, (2004)

Solubility :
Soluble in DMSO: 18 mg/mL
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16079003
SMILES :
CC1=CC2=C(C=C1)N(C=C2CC(C(=O)O)NC(=O)C3=CC=CC=C3OC4=CC=CC=C4)C(=O)OCC5=CC=CC=C5

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Certificate of Analysis

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