R(-)-Deprenyl hydrochloride A neuroprotective agent and inhibitor of MAO-B

R(-)-Deprenyl hydrochloride (CAS 14611-52-0)

R(-)-Deprenyl hydrochloride | CAS 14611-52-0 is rated 5.0 out of 5 by 1.
  • y_2018, m_12, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200742, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 38ms
  • REVIEWS, PRODUCT
Synonym: Selegiline hydrochloride
Application: A neuroprotective agent and inhibitor of MAO-B
CAS Number: 14611-52-0
Purity: 98%
Molecular Weight: 223.74
Molecular Formula: C13H17N•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

R(-)-Deprenyl hydrochloride is the hydrochloride salt preparation of R(-)-Deprenyl, an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. R(-)-Deprenyl demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. R(-)-Deprenyl also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B. The GAPDH (glyceraldehyde-3-phosphate dehydrogenase) enzyme is implicated as a potential mediator of R(-)-Deprenyl-induced neuroprotection - reported to interact with proteins implicated in neurodegeneration and to activate transcription in neuronal cells, GAPDH has also been shown to directly interact with CGP 3466, a close structural and functional analog of R(-)-Deprenyl.


References

1. Lewin, R. 1985. Science. 230: 527-528. PMID: 3931220
2. Tetrud, J.W., et al. 1989. Science. 245: 519-522. PMID: 2502843
3. Tatton, W.G., et al. 1991. J. Neurosci. Res. 30: 666-672. PMID: 1686284
4. Tatton, W.G., et al. 1994. J. Neurochem. 63: 1572-1575. PMID: 7931312
5. Kragten, E., et al. 1998. J. Biol. Chem. 273: 5821-5828. PMID: 9488718

Physical State :
Solid
Solubility :
Soluble in water (25 mg/ml), chloroform, ethanol, and methanol.
Storage :
Store at room temperature
Melting Point :
141.1-142.2° C
Optical Activity :
α25/D -10.8°, c = 6.48 in water
pK Values :
pKb: 7.53 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DA0292500
PubChem CID :
26758
Merck Index :
14: 8428
MDL Number :
MFCD00069299
SMILES :
C[C@H](CC1=CC=CC=C1)N(C)CC#C.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 54ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Mihalik Mihalik, et al. treated male rats with R(-)-deprenyl and found that the epididymis that was exposed to this drug had a higher sperm count and the females that mated with these rats gave birth to a greater number of offspring, when compared to the control. -SCBT Publication Review
Date published: 2015-03-21
  • y_2018, m_12, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_2.0.9
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_200742, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 231ms
  • REVIEWS, PRODUCT
--%>

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2018 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.