Quinupristin Used commercially in synergistic combination with dalfopristin

Quinupristin (CAS 120138-50-3)

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Synonym: AC1LAKMS
Application: Used commercially in synergistic combination with dalfopristin
CAS Number: 120138-50-3
Molecular Weight: 1022.2
Molecular Formula: C53H67N9O10S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, Streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in alcohol, water (slightly), and DMSO.
Storage :
Store at -20° C
Density :
1.39 g/cm3
Refractive Index :
n20D 1.66
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
470126
MDL Number :
MFCD00865105
SMILES :
CCC1C(=O)N2CCC[C@H]2C(=O)N([C@H](C(=O)N3C[C@H](C(=O)CC3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CS[C@@H]6CN7CCC6CC7)CC8=CC=C(C=C8)N(C)C)C

Download SDS (MSDS)

Certificate of Analysis

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