Quinomycin A is a cyclodepsipeptide metabolite of the quinoxaline family that exhibits various antibiotic, antiviral, and antitumor activity. Quinomycin A has been demonstrated to bind strongly to DNA at sites containing the central two-base-pair sequence 5'-CG-3'. Quinomycin A was observed to induce apoptosis in human colon cancer cells (HT-29) with activity associated with cytochrome c release and stimulations of ERK and caspase-3. Quinomycin A reportedly inhibits HIF by blocking binding of HIF-1α and HIF-1β proteins to a HRE sequence, and by blocking hypoxic induction of luciferase in U251-HRE cells and VEGF mRNA expression in U251 cells.
1. Wakelin, S.P., et al. 1976. Biochem. J. 157: 721-740. PMID: 985413
2. Van Dyke, M.M., et al. 1984. Science. 225: 1122-1127. PMID: 6089341
3. Kong, D., et al. 2005. Cancer Res. 65: 9047-9055. PMID: 16204079
4. Park, J.Y., et al. 2006. Int. J. Biochem. Cell Biol. 38: 244-254. PMID: 16214385
See how others have used Quinomycin A. Click on the entry to view the PubMed entry .
PMID: # 25862859 Cha, W. et al. 2015. Anticancer Res. 35: 2049-54.
PMID: # 19574634 Pfoh, R. et al. 2009. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 660-664.
PMID: # 15177310 Park, JY. et al. 2004. Pharmacol. Res. 50: 201-207.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.