Quinaldopeptin A bis-intercalating cyclic peptide antibiotic

Quinaldopeptin (CAS 130743-07-6)

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Application: A bis-intercalating cyclic peptide antibiotic
CAS Number: 130743-07-6
Purity: >95%
Molecular Weight: 1243.4
Molecular Formula: C62H78N14O14
* Refer to Certificate of Analysis for lot specific data (including water content).
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Quinaldopeptin is a quinomycin antibiotic isolated from a Streptoverticillium album strain with strong antimicrobial and cytotoxic activity. The symmetric cyclic peptide structure of Quinaldopeptin contains two intercalating naphtyl moieties which produce a bis-intercalation of DNA base pairs, creating DNA crosslinks and disturbing natural DNA processes. Quinaldopeptin is demonstrated to have high efficacy against gram-positive bacteria and cultured B16 melanoma cells.


1. Toda, S., et al. 1990. J. Antibiot. 43: 796-808. PMID: 2387774
2. Rickards, R.W., et al. 1998. J. Antibiot. 51: 1093-1098. PMID: 10048568

Appearance :
Physical State :
Derived From :
Amycolatopsis sp.
Solubility :
Soluble in methanol, DMSO, and DMF.
Storage :
Store at 4° C
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
HIV-1(RF): IC50 = 0.43 µM (CEM); HIV-1(RF): EC5050 >10.5 µM (CEM)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

Download SDS (MSDS)

Certificate of Analysis

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