Quinacrine, Dihydrochloride A non-specific PLA2 inhibitor. and acetylcholine receptor antagonist

Quinacrine, Dihydrochloride (CAS 69-05-6)

Quinacrine, Dihydrochloride | CAS 69-05-6 is rated 5.0 out of 5 by 2.
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Synonym: Atebrine; Mepacrine; Malaricida
Application: A non-specific PLA2 inhibitor. and acetylcholine receptor antagonist
CAS Number: 69-05-6
Purity: ≥95%
Molecular Weight: 472.88
Molecular Formula: C23H30ClN3O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Quinacrine dihydrochloride is a non-specific PLA2 (phospholipase A2) inhibitor. Quinacrine, Dihydrochloride acts as an AChR (acetylcholine receptor) antagonist. Quinacrine dihydrochloride suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 μM). This compound also inhibits MAO (monoamine oxidase). Quinacrine, Dihydrochloride is an inhibitor of cPLA2, MAO-A and MAO-B.


References

Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206. Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117. Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161. Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33. Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun. 181,714.

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml with heat, yielding a clear solution), and ethanol (slightly). Insoluble in alcohol, benzene, chloroform, and ether.
Storage :
Store at room temperature
Melting Point :
257° C
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 0.08 nM; Phospholipase A2: IC50 = 17 µM (porcine pancreas); Human immunodeficiency virus 1: IC50 = 2.15 µM; cPLA2: IC50 = 200 µM (bovine brain); Glibenclamide-sensitive K+-currents: IC50 = 4.4 µM
Fluoresence :
λex 417 nm, λem 496 nm in 30 mM Tris; 0.2 M sucrose
pK Values :
pKa: pK1: 7.7, pK2: 10.3, pKb: 10.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AR7875000
PubChem CID :
6239
Merck Index :
14: 8044
MDL Number :
MFCD00012659
EC Number :
200-700-8
Beilstein Registry :
4834013
SMILES :
CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Worked for our bacterial experiment! We purchased this project a few week ago and used it for our bacterial experiments. The quality was good.
Date published: 2018-08-02
Rated 5 out of 5 by from Zapata Zapata-Mart nez, J. et al. (PubMed 26350822) investigated the involvement of phosphoinositide metabolism, especially the participation of PLA2 in dehydroleucodine (DhL)-induced activation of Rhinella arenarum oocytes. They found that introduction of Quinacrine, a non-specific PLA2 inhibitor, did not affect DhL-induced activation. -SCBT Publication Review
Date published: 2015-01-06
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