Quinacrine dihydrochloride is a non-specific PLA2 (phospholipase A2) inhibitor. Quinacrine, Dihydrochloride acts as an AChR (acetylcholine receptor) antagonist. Quinacrine dihydrochloride suppresses glibenclamide-sensitive K+-currents (IC50 = 4.4 μM). This compound also inhibits MAO (monoamine oxidase). Quinacrine, Dihydrochloride is an inhibitor of cPLA2, MAO-A and MAO-B.
Holscher, C. 1995. Neurobiol. Learn. Mem. 63, 206. Sakuta, H. and Yoneda, I. 1994. Eur. J. Pharmacol. 252, 117. Sargent, C.A., et al 1992. J. Pharmacol. Exp. Ther. 262, 1161. Voorhis, B.J., et al. 1992. Invertebr. Reprod. Dev. 21, 33. Murakami, M., et al. 1991. Biochem. Biophys. Res. Commun. 181,714.
Soluble in water (50 mg/ml with heat, yielding a clear solution), and ethanol (slightly). Insoluble in alcohol, benzene, chloroform, and ether.
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Rated 5 out of
Worked for our bacterial experiment!We purchased this project a few week ago and used it for our bacterial experiments. The quality was good.
Date published: 2018-08-02
Rated 5 out of
ZapataZapata-Mart nez, J. et al. (PubMed 26350822) investigated the involvement of phosphoinositide metabolism, especially the participation of PLA2 in dehydroleucodine (DhL)-induced activation of Rhinella arenarum oocytes. They found that introduction of Quinacrine, a non-specific PLA2 inhibitor, did not affect DhL-induced activation. -SCBT Publication Review
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