Q-VD-OPH An inhibitor of caspase-3, caspase-1, caspase-8 and caspase-9

Q-VD-OPH (CAS 1135695-98-5)

Q-VD-OPH | CAS 1135695-98-5 is rated 5.0 out of 5 by 1.
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Synonym: pan-Caspase inhibitor (fluoromethylketone); N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy) methylketone
Application: An inhibitor of caspase-3, caspase-1, caspase-8 and caspase-9
CAS Number: 1135695-98-5
Purity: ≥95%
Molecular Weight: 513.8
Molecular Formula: C26H25F2N3O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.


References

1. Rebbaa, Abdelhadi., et al., 2003. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene. 22(18): 2805-11. PMID: 12743603
2. Caserta, T M., et al., 2003. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis : an international journal on programmed cell death. 8(4): 345-52. PMID: 12815277
3. Patil, Kiran., et al., 2004. Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia. Neuroreport. 15(6): 981-4. PMID: 15076719

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
Storage :
Store at -20° C
Boiling Point :
808.87° C at 760 mmHg (Predicted)
Density :
1.35 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
caspase-3: IC50 <25 nM; caspase-1: IC50 = 50 nM; caspase-8: IC50 = 100 nM; caspase-9: IC50 = 430 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11237609
MDL Number :
MFCD08669741
SMILES :
CC(C)C(C(=O)NC(CC(=O)O)C(=O)COC1=C(C=CC=C1F)F)NC(=O)C2=NC3=CC=CC=C3C=C2

Download SDS (MSDS)

Certificate of Analysis

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Q-VD-OPH  Product Citations

See how others have used Q-VD-OPH. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26243583  Wang, H. et al. 2015. Nat Commun. 6: 7916.

PMID: # 24173220  Alymova, IV. et al. 2014. J. Virol. 88: 503-15.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Keoni CL; et al Keoni CL; et al. (PubMed ID: 25922583) determined that Q-VD-OPH is the perferred inhibitor of pancaspase due to it's non-toxic properties in cells. -SCBT Publication Review
Date published: 2015-03-21
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