Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
1. Rebbaa, Abdelhadi., et al., 2003. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene. 22(18): 2805-11. PMID: 12743603
2. Caserta, T M., et al., 2003. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis : an international journal on programmed cell death. 8(4): 345-52. PMID: 12815277
3. Patil, Kiran., et al., 2004. Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia. Neuroreport. 15(6): 981-4. PMID: 15076719
See how others have used Q-VD-OPH. Click on the entry to view the PubMed entry .
PMID: # 27123694 Strappazzon, F. et al. 2016. Autophagy. 12: 963-75.
PMID: # 26243583 Wang, H. et al. 2015. Nat Commun. 6: 7916.
PMID: # 24173220 Alymova, IV. et al. 2014. J. Virol. 88: 503-15.
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