Q-VD-OPH is a selective, brain and cell permeable, highly potent and irreversible inhibitor of caspase-3 ( IC50=25nm), caspase-1 (IC50=50nM), caspase-8 (IC50=100nM) and caspase-9 (IC50=430nM). It protects neurotoxin-insulted neurons from apoptotic death, as well as displays minimal toxicity. In order to reduce hydrophobicity of the peptide and to facilitate the use in aqueous media the aspartyl residue of the inhibitor is not o-methylated.
1. Rebbaa, Abdelhadi., et al., 2003. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene. 22(18): 2805-11. PMID: 12743603
2. Caserta, T M., et al., 2003. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis : an international journal on programmed cell death. 8(4): 345-52. PMID: 12815277
3. Patil, Kiran., et al., 2004. Broad spectrum caspase inhibitor rescues retinal ganglion cells after ischemia. Neuroreport. 15(6): 981-4. PMID: 15076719
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Keoni CL; et alKeoni CL; et al. (PubMed ID: 25922583) determined that Q-VD-OPH is the perferred inhibitor of pancaspase due to it's non-toxic properties in cells. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.