Pyrrolidinedithiocarbamic acid ammonium salt An NF kappa B inhibitor with antioxidant properties

Pyrrolidinedithiocarbamic acid ammonium salt (CAS 5108-96-3)

Pyrrolidinedithiocarbamic acid ammonium salt | CAS 5108-96-3 is rated 5.0 out of 5 by 1.
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Application: An NF kappa B inhibitor with antioxidant properties
CAS Number: 5108-96-3
Purity: ≥98%
Molecular Weight: 164.28
Molecular Formula: C5H8NS2•NH4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pyrrolidinedithiocarbamic acid (PDTC) ammonium salt is a potent inhibitor of NF κB (Nuclear Factor κB). Experiments show that micromolar amounts of this compound suppress IL-1β and completely inhibit the increase of nitric oxide synthase mRNA in response to IL-1β. Further studies suggest that PDTC ammonium salt also displays metal-ion chelating and antioxidant characteristics.


References

1. Eberhardt, W., et al. 1994. Biochem. Biophys. Res. Commun. 200: 163-170. PMID: 7513157
2. Bessho, R., et al. 1994. Biochem. Pharmacol. 48: 1883-1889. PMID: 7986199
3. Schini-Kerth, V., et al. 1994. Eur. J. Pharmacol. 265: 83-87. PMID: 7533726

Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), ethanol, chloroform, and DMSO (100 mM).
Storage :
Store at 4° C
Melting Point :
153-155° C (lit.)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
U-937: IC50 = 8.3 µg/ml (human)
Ki Data :
CA I: Ki= 0.96 nM (human); CA II: Ki= 27.5 nM (human); CA XII: Ki= 46.1 nM (human); CA IX: Ki= 70.4 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY0281650
PubChem CID :
73343
MDL Number :
MFCD00012720
EC Number :
225-834-4
Beilstein Registry :
3730472
SMILES :
[NH4+].[S-]C(=S)N1CCCC1

Download SDS (MSDS)

Certificate of Analysis

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Pyrrolidinedithiocarbamic acid ammonium salt  Product Citations

See how others have used Pyrrolidinedithiocarbamic acid ammonium salt. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 28288190  Chen, S. et al. 2017. PLoS ONE. 12: e0173725.

PMID: # 26479035  Zhang, L. et al. 2015. Nature. 527: 100-4.

PMID: # 26693060  Liu, LB. et al. 2015. Am J Cancer Res. 5: 3072-84.

PMID: # 24371447  Meng, T. et al. 2013. Clin. Dev. Immunol. 2013: 325481.

PMID: # 22288713  Sun, R. et al. 2012. Cell Biol. Int. 36: 475-81.

Lau, H et al. 1971. Analytica chimica acta. 56: 7-16.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Zhi Zhi, Y. et al. (PubMed 25503960) used Pyrrolidinedithiocarbamic acid ammonium salt, a known NF B and IL-1 inhibitor, to determine the role of NF B signaling pathway in the regulation of CXCR4 expression in neuroblastoma cells induced by TNF- . Introduction of Pyrrolidinedithiocarbamic acid ammonium salt successfully inhibited the NF B pathway, thereby suppressing TNF- induced upregulation of CXCR4 expression. -SCBT Publication Review
Date published: 2015-07-16
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