Pyridoxal Isonicotinoyl Hydrazone is a cell-permeable, non-toxic, iron (Fe3+) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe3+ from cells and even at low concentrations, prevents its uptake from transferrin. Pyridoxal Isonicotinoyl Hydrazone exhibits similar binding affinity and specificity as Desferrioxamine, but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Pyridoxal Isonicotinoyl Hydrazone inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.
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See how others have used Pyridoxal Isonicotinoyl Hydrazone. Click on the entry to view the PubMed entry .
PMID: # 26033732 Abdalla, MY. et al. 2015. Antimicrob. Agents Chemother. 59: 4826-34.
PMID: # 25822972 Hayashi, M. et al. 2015. PloS one. 10: e0122351.
PMID: # 26006106 Dev, S. et al. 2015. Free Radic. Biol. Med. 86: 78-89.
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