Pyrazinamide An antibacterial agent used to study liver toxicity prevention

Pyrazinamide (CAS 98-96-4)

Pyrazinamide | CAS 98-96-4 is rated 5.0 out of 5 by 1.
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Synonym: Pyrazinecarboxamide; Pyranzinoic acid amide
Application: An antibacterial agent used to study liver toxicity prevention
CAS Number: 98-96-4
Purity: ≥98%
Molecular Weight: 123.11
Molecular Formula: C5H5N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pyrazinamide is an antibacterial agent used to form polymeric copper complexes. It is also useful for studying liver toxicity prevention. Further, the active moiety of pyrazinamide, pyrazinoic acid (POA), is believed to interfere with membrane energetics and transport function in Mycobacterium tuberculosis.


References

1. Zhang, Y., et al., 2003. The curious characteristics of pyrazinamide: a review. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 7(1): 6-21. PMID: 12701830

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), methanol (13.8 mg/ml at 25° C), ethanol (5.7 mg/ml at 25° C), chloroform (7.4 mg/ml at 25° C), and DMSO.
Storage :
Store at room temperature
Melting Point :
189-191° C (lit.)
Boiling Point :
357° C (Predicted)
Density :
1.4 (Predicted)
Refractive Index :
n20D ~1.58 (Predicted)
IC50 :
Fatty acid synthase 1: IC50 = 8.93 mM (Mycobacterium tuberculosis); HepG2: IC50 = 79.1 mM (human)
Ki Data :
Fatty acid synthase 1: Ki= 41 µM (Mycobacterium tuberculosis); Fatty acid synthase 1 expressed in Mycobacterium smegmatis mc2 2700: Ki= 2.57 mM (Mycobacterium tuberculosis)
pK Values :
pKa: 0.5, 13.91 (Predicted), pKb: 0.87 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UQ2275000
PubChem CID :
1046
Merck Index :
14: 7956
MDL Number :
MFCD00006132
EC Number :
202-717-6
Beilstein Registry :
112306
SMILES :
C1=CN=C(C=N1)C(=O)N

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Certificate of Analysis

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Rated 5 out of 5 by from Prideaux et al Prideaux et al. (PubMed ID 26343800) showed that the sterilizing drug, pyrazinamide, successfully penetrated sites of TB infection in lung lesions. -SCBT Publication Review
Date published: 2015-01-03
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