Pyrazinamide is an antibacterial agent used to form polymeric copper complexes. It is also useful for studying liver toxicity prevention. Further, the active moiety of pyrazinamide, pyrazinoic acid (POA), is believed to interfere with membrane energetics and transport function in Mycobacterium tuberculosis.
1. Zhang, Y., et al., 2003. The curious characteristics of pyrazinamide: a review. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 7(1): 6-21. PMID: 12701830
Soluble in water (50 mg/ml), methanol (13.8 mg/ml at 25° C), ethanol (5.7 mg/ml at 25° C), chloroform (7.4 mg/ml at 25° C), and DMSO.
Store at room temperature
189-191° C (lit.)
357° C (Predicted)
n20D ~1.58 (Predicted)
Fatty acid synthase 1: IC50 = 8.93 mM (Mycobacterium tuberculosis); HepG2: IC50 = 79.1 mM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Prideaux et alPrideaux et al. (PubMed ID 26343800) showed that the sterilizing drug, pyrazinamide, successfully penetrated sites of TB infection in lung lesions. -SCBT Publication Review
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