Purvalanol A A selective inhibitor of cyclin-dependent kinases

Purvalanol A (CAS 212844-53-6)

Purvalanol A | CAS 212844-53-6 is rated 5.0 out of 5 by 2.
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Synonym: 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine
Application: A selective inhibitor of cyclin-dependent kinases
CAS Number: 212844-53-6
Purity: ≥99%
Molecular Weight: 388.89
Molecular Formula: C19H25ClN6O
* Refer to Certificate of Analysis for lot specific data (including water content).
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Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (Cdks). IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Purvalanol A reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Physical State :
Solid
Solubility :
Soluble in methylene chloride (50 mg/ml), DMSO (100 mg/ml), ethanol (50 mM), methanol, and dichloromethane.
Storage :
Store at -20° C
Melting Point :
243.74° C (Predicted)
Boiling Point :
590.47° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
cdc2/cyclin B: IC50 = 4 nM; Cdc2 p34: IC50 = 4 nM (human); Cdk2: IC50 = 4 nM (human); cdk2/cyclin E: IC50 = 35 nM; cdk2/cyclin A: IC50 = 70 nM
pK Values :
pKb: 4.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
456214
MDL Number :
MFCD02179211
Beilstein Registry :
8645511
SMILES :
CC(C)[C@H](CO)NC1=NC2=C(C(=N1)NC3=CC(=CC=C3)Cl)N=CN2C(C)C

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Certificate of Analysis

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Purvalanol A  Product Citations

See how others have used Purvalanol A. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26549230  Mori, Y. et al. 2015. Biochemical and biophysical research communications. 468: 642-6.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Good product! We purchased this product several times and it works well.
Date published: 2016-12-04
Rated 5 out of 5 by from A decrease in survivin protein expression A decrease in survivin protein expression was observed by WB in HeLa cells post treatment with Cdk2 Inhibitor IV, NU6140 and Purvalanol. -SCBT QC
Date published: 2015-01-20
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