Puromycin Aminonucleoside An aminonucleoside portion of the antibiotic puromycin

Puromycin Aminonucleoside (CAS 58-60-6)

Puromycin Aminonucleoside | CAS 58-60-6 is rated 5.0 out of 5 by 1.
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Application: An aminonucleoside portion of the antibiotic puromycin
CAS Number: 58-60-6
Purity: ≥98%
Molecular Weight: 294.3
Molecular Formula: C12H18N6O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Puromycin Aminonucleoside (3'-Amino-3'-deoxy-N6,N6-dimethyladenosine) is the aminonucleoside portion of the antibiotic puromycin. It is a puromycin analog which does not inhibit protein synthesis or induce apoptosis. Used in the study of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and NOx metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome has been studied. Used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.


References

1. Gwinner, W., et al. 1997. J. Am. Soc. Nephrol. 8: 1722-1731. PMID: 9355075
2. Shirato, I., et al. 2000. J. Am. Soc. Nephrol. 11: 2381-2386. PMID: 11095662
3. Sörensson, J., et al. 2003. Am. J. Physiol. Renal Physiol. 284: F373-F380. PMID: 12388398
4. Ni, Z. and Vaziri, N.D. 2003. Biochim. Biophys. Acta. 1638: 129-137. PMID: 12853118
5. McDonough, A.A., et al. 2003. Curr. Opin. Nephrol. Hypertens. 12: 533-541. PMID: 12920402
6. Mattoo, T.K. and Kovacevic, L. 2003. Pediatr. Nephrol. 18: 872-877. PMID: 12836089
7. Fogo, A.B. 2003. Semin. Nephrol. 23: 161-171. PMID: 12704576
8. Bae, E.H., et al. 2009. Korean J. Physiol. Pharmacol. 13: 1-7. PMID: 19885019

Usage :
• This product is not for selection and maintenance of cell lines expressing a transfected pac gene. For the selection of stably transfected cells following transfection with Santa Cruz Biotechnology shRNA or Lentiviral particles, we recommend the following: Puromycin dihydrochloride (sc-108071)
Physical State :
Solid
Derived From :
Semisynthetic, from Puromycin
Solubility :
Soluble in water (10 mg/ml)
Storage :
Store at -20° C
Melting Point :
330.39° C (lit.) (Predicted)
Boiling Point :
752° C at 760 mmHg (Predicted)
Density :
1.71 g/cm3
Refractive Index :
n20D 1.78
pK Values :
pKa: 13.26, pKb: 7.59
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7337000
PubChem CID :
6020
MDL Number :
MFCD00063462
EC Number :
200-388-3
Beilstein Registry :
93902
SMILES :
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)N)O

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Certificate of Analysis

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Puromycin Aminonucleoside  Product Citations

See how others have used Puromycin Aminonucleoside. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 26101708  Wu, W. et al. 2015. American journal of cancer research. 5: 1435-46.

PMID: # 24260371  Müller-Krebs, S. et al. 2013. PLoS ONE. 8: e80340.

Citations 1 to 2 of 2 total

Is this soluble in anything other than water?

Asked by: SCchem16
Thank you for your question. This chemical, Puromycin Aminonucleoside: sc-200112, is soluble at ~5 mg/ml in PBS (pH 7.2), ~20 mg/ml in DMSO and ~10 mg/ml in DMF
Answered by: Chemical Support 2
Date published: 2017-03-02

Can a 5mg/ml solution in PBS be filtered through a 0.2 or 0.45 micron filter?

Asked by: bw1234
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Rated 5 out of 5 by from Wen Wen, et al. (PubMed ID 26014479) used puromycin aminonucleoside (PAN) to cause kidney disease in Wistar rats in order to test the effectiveness of Yi Qi Qing Re Gao (YQQRG) formula in treatment of the resulting nephrosis. -SCBT Publication Review
Date published: 2015-07-05
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