PTP1B SubstrateA synthetic substrate for PTP1B

PTP1B Substrate

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Synonym: DADEpYLIPQQG; [pTyr992] EGF receptor (988-998)
Application: A synthetic substrate for PTP1B
Purity: ≥92%
Molecular Weight: 1330.3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP1B Substrate (DADEpYLIPQQG) is a biologically active peptide derived from an autophosphorylation site (Tyr992) of epidermal growth factor receptor (EGFR). An excellent synthetic substrate for mammalian PTP1B and Yersinia PTPase. May be used in non-radioactive phosphatase assays for colorimetric phosphate quantitation.


References

1. Martin, B., Pallen, C.J., Wang, J.H. and Graves, D.J. 1985. Use of fluorinated tyrosine phosphates to probe the substrate specificity of the low molecular weight phosphatase activity of calcineurin. J. Biol. Chem. 260(28): 14932-14937. PMID: 2415511
2. Zhang, Z.Y., Maclean, D., Thieme-Sefler, A.M., Roeske, R.W. and Dixon, J.E. 1993. A continuous spectrophotometric and fluorimetric assay for protein tyrosine phosphatase using phosphotyrosine-containing peptides. Anal. Biochem. 211(1): 7-15. PMID: 7686722
3. Zhang, Z.Y., Thieme-Sefler, A.M., Maclean, D., McNamara, D.J., Dobrusin, E.M., Sawyer, T.K. and Dixon, J.E. 1993. Substrate specificity of the protein tyrosine phosphatases. Proc. Natl. Acad. Sci. U.S.A. 90(10): 4446-4450. PMID: 7685104
4. Harder, K.W., Owen, P., Wong, L.K., Aebersold, R., Clark-Lewis, I. and Jirik, F.R. 1994. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem. J. 298(Pt2) : 395-401. PMID: 8135747
5. Sarmiento, M., Zhao, Y., Gordon, S.J. and Zhang, Z.Y. 1998. Molecular basis for substrate specificity of protein-tyrosine phosphatase 1B. J. Biol. Chem. 273(41): 26368-26374. PMID: 9756867

Appearance :
Lyophilized powder
Physical State :
Solid
Sequence :
Asp-Ala-Asp-Glu-pTyr-Leu-Ile-Pro-Gln-Gln-Gly
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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PTP1B Substrate  Product Citations

See how others have used PTP1B Substrate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 24668740  2014. Molecular nutrition & food research. 58: 1177-89.

PMID: # 22824864  Kimura, K. et al. 2012. Free radical biology & medicine. 53: 1239-51.

PMID: # 18579758  Kakazu, A. et al. 2008. Investigative ophthalmology & visual science. 49: 2927-35.

Citations 1 to 3 of 3 total

What should I re-suspend this product in?

Asked by: Johnathan
Thank you for your question. Please resuspend this question in water. If you have any further questions, please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com.
Answered by: Tech Service
Date published: 2018-04-18
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