PTP Inhibitor V, PHPS1 A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2

PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

PTP Inhibitor V, PHPS1 | CAS 314291-83-3 is rated 5.0 out of 5 by 1.
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Synonym: PhenylHydrazonoPyrazolone Sulfonate 1
Application: A cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2
CAS Number: 314291-83-3
Purity: ≥95%
Molecular Weight: 465.45
Molecular Formula: C21H15N5O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC50 and Ki = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC50 = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.


References

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

Usage :
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml).
Storage :
Store at 4° C
IC50 :
Shp-2: IC50 = 2.1 µM; EC50PTP: IC50 = 5.4 µM; PTP1B: IC50 = 19 µM; Shp1: IC50 = 30 µM; mycobacterium MptpA: IC50 = 39 µM
Ki Data :
Shp-2: Ki= 0.73 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
71433536
SMILES :
[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

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Certificate of Analysis

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PTP Inhibitor V, PHPS1  Product Citations

See how others have used PTP Inhibitor V, PHPS1. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 22878065  Gupta, VK. et al. 2012. Biochim. Biophys. Acta. 1822: 1643-9.

PMID: # 23189174  Tsang, YH. et al. 2012. PLoS ONE. 7: -.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Li Li, S. et al. (PubMed 25331952) used the SHP2 inhibitor PHPS1 to demonstrate that SHP2 positively regulates TGF 1-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1. -SCBT Publication Review
Date published: 2015-04-10
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