Psoralen A photochemical probe in studies of DNA mutation and repair mechanisms

Psoralen (CAS 66-97-7)

Psoralen | CAS 66-97-7 is rated 5.0 out of 5 by 1.
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Synonym: Ficusin
Application: A photochemical probe in studies of DNA mutation and repair mechanisms
CAS Number: 66-97-7
Purity: ≥98%
Molecular Weight: 186.16
Molecular Formula: C11H6O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Psoralen is used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human. Shows antiviral, antibacterial, antifungal and insecticidal properties.


References

1. Kornhauser, A., et al. 1982. Science. 217: 733-735. PMID: 7100920
2. Cimino, G.D., et al. 1985. Annu. Rev. Biochem. 54: 1151-1193. PMID: 2411210
3. Inman, R.B. and Schnos, M. 1987. J. Mol. Biol. 193: 377-384. PMID: 2955121
4. Ussery, D.W., et al. 1992. Meth. Enzymol. 212: 242-262. PMID: 1325599
5. Cullinane, C. and Bohr, V.A. 1998. Cancer Res. 58: 1400-1404. PMID: 9537239
6. Toussaint, M., et al. 2005. Biochem. Cell Biol. 83: 449-459. PMID: 16094448
7. Couve-Privat, S., et al. 2007. Nucl. Acids Res. 35: 5672-5682. PMID: 17715144
8. Kim, K.H., et al. 2007. Nucl. Acids Res. 35: 7604-7613. PMID: 17977869

Appearance :
Powder
Physical State :
Solid
Derived From :
Psoralea corylifolia
Solubility :
Soluble in ethanol (10 mg/ml), ethyl acetate, acetone, and water (1.93 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
163-164° C
Boiling Point :
~362.6° C at 760 mmHg (Predicted)
Density :
~1.40 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
NF-KB p50 subunit/DNA interaction: IC50 = 3 nM; NF°B p50, or NF°B p105: IC50 = 3 µM (human); calf thymus DNA topoisomerase 1: IC50 = 11 µM; LoVo: IC50 = 16 µM (human); HEK293: IC50 = 167 µM (human)
Ki Data :
CYP2A6: Ki= 600 nM (human)
Fluoresence :
λex 335 nm, λem 460 nm(pH 7.0)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV0944000
PubChem CID :
6199
Merck Index :
14: 7928
MDL Number :
MFCD00010520
EC Number :
200-639-7
Beilstein Registry :
152784
SMILES :
C1=CC(=O)OC2=CC3=C(C=CO3)C=C21

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Psoralen  Product Citations

See how others have used Psoralen. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28069007  Zarmouh, NO. et al. 2017. BMC Complement Altern Med. 17: 34.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Yang Yang, et al. (PubMed ID 25796142) reports that psoralen can remit the degeneration of lumbar intervetebral disc induced by IL-1beta to some extent. It can also affect the related factors of this signaling pathway. -SCBT Publication Review
Date published: 2015-04-06
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