Pseudolaric acid B

Pseudolaric acid B (CAS 82508-31-4)

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Synonym: Pseudolarix acid B
Application: A PPARα and PLC activator
CAS Number: 82508-31-4
Purity: ≥95%
Molecular Weight: 432.5
Molecular Formula: C23H28O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pseudolaric acid B activates PPARα and the phospholipase C (PLC) signaling pathway. Stimulates peroxisomal fatty acyl-CoA oxidase activity. These effects can be blocked by staurosporine. Pseudolaric acid B exhibits significant cytotoxic activities against numerous tumor cell lines. Pseudolaric acid B binds Tubulin, inhibits angiogenesis, reduces HIF-1α protein levels, induces apoptosis, and is an antifungal.


References

Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47, 35 (1983) The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56, 383 (1990) Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58, 57 (1995) Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68, 667 (2002) Five new diterpenoids from Pseudolarix kaempferi: S.P. Yang, et al.; J. Nat. Prod. 65, 1041 (2002) Antifungal diterpenoids of Pseudolarix kaempferi, and their structure-activity relationship study: S.P. Yang, et al.; Bioorg. Med. Chem. 11, 4577 (2003) Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004) Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004) Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005) Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005) Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005) Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006) Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death: X. Gong, et al.; Exp. Mol. Med. 38, 428 (2006) Studies on anti-tumour activities of pseudolaric acid-B (PLAB) and its mechanism of action: B. Liu, et al.; J. Asian Nat. Prod. Res. 8, 241 (2006) Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene: J.K. Ko, et al.; Eur. J. Pharmacol. 559, 1 (2007) Structural modification of an angiogenesis inhibitor discovered from traditional chinese medicine and a structure-activity relationship study: S.P. Yang, et al.; J. Med. Chem. 51, 77 (2008)

Physical State :
Solid
Derived From :
Pseudolarix kaempferi
Solubility :
Soluble in DMSO, 100% ethanol or chloroform
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
6436202
SMILES :
CC(=CC=CC1(C2CCC3(C2(CCC(=CC3)C(=O)OC)C(=O)OC)C(=O)O1)C)C(=O)O

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