Psammaplin A A DNA methyltransferase inhibitor

Psammaplin A (CAS 110659-91-1)

Psammaplin A | CAS 110659-91-1 is rated 5.0 out of 5 by 1.
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Synonym: Bisprasin
Application: A DNA methyltransferase inhibitor
CAS Number: 110659-91-1
Purity: ≥97%
Molecular Weight: 664.39
Molecular Formula: C22H24Br2N4O6S2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Psammaplin A is an antibiotic, anti-tumor, DNA methyltransferase (Dnmt) inhibitor. It is a bromotyrosine-derived, symmetrical conjugate of cystamine, which was first isolated from the Psammaplinaplysilla sponge. Impedes angiogenesis as well as bacterial and tumor cell growth. Inhibits the activities of several key enzymes in prokaryotic and eukaryotic systems including those involved in epigenetic control of gene expression, DNA replication, angiogensis, and microbial detoxification.


References

1. Kim, T.H. et al. 2015. Biochim. Biophys. Acta. 1850(2): 401-410. PMID: 25445714

Physical State :
Solid
Solubility :
Soluble in DMSO: >10 mg/mL: water: insoluble
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6400741
SMILES :
C1=CC(=C(C=C1C/C(=N\O)/C(=O)NCCSSCCNC(=O)/C(=N/O)/CC2=CC(=C(C=C2)O)Br)Br)O

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Certificate of Analysis

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Psammaplin A  Product Citations

See how others have used Psammaplin A. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25749170  Mallol, A. et al. 2015. PLoS ONE. 10: e0120033.

PMID: # 25445714  Kim, TH. et al. 2015. Biochimica et biophysica acta. 1850: 401-10.

PMID: # 25068567  Mallol, A. et al. 2014. Cell Reprogram. 16: 392-406.

Citations 1 to 3 of 3 total

Is Psammaplin A synthetic or from a native source, such as a sponge?

Asked by: ChemSynth123
Thank you for your question. Psammaplin A (CAS 110659-91-1): sc-258049 is synthetic and not derived from a biological source.
Answered by: Chemical Support 7
Date published: 2017-03-11
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Rated 5 out of 5 by from Kim Kim, TH. et al. (PubMed 25445714) found that Psammaplin A, a DNA methyltransferase inhibitor, induces SIRT1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. -SCBT Publication Review
Date published: 2015-03-18
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