PrulifloxacinA compound with broad spectrum antibacterial activity

Prulifloxacin (CAS 123447-62-1)

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Synonym: Quisnon; Pruvel
Application: A compound with broad spectrum antibacterial activity
CAS Number: 123447-62-1
Purity: ≥98%
Molecular Weight: 461.46
Molecular Formula: C21H20FN3O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Prulifloxacin is a fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Prulifloxacin is an inhibitor of Topo II.


References

In vivo evaluation of NM441, a new thiazeto-quinoline derivative: M. Ozaki, et al.; Antimicrob. Agents Chemother. 35, 2496 (1991) Studies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4- oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3- carboxylic acids: J. Segawa, et al.; J. Med. Chem. 35, 4727 (1992) Pharmacokinetics and safety of NM441, a new quinolone, in healthy male volunteers: M. Nakashima, et al.; J. Clin. Pharmacol. 34, 930 (1994) Randomized, double-blind study of prulifloxacin versus ciprofloxacin in patients with acute exacerbations of chronic bronchitis: C. Grassi, et al.; Respiration 69, 217 (2002) Pharmacologic characteristics of prulifloxacin: M.G. Matera; Pulm. Pharmacol. Ther. 19, 20 (2006) Prulifloxacin: a new fluoroquinolone for the treatment of acute exacerbation of chronic bronchitis: M. Cazzola, et al.; Pulm. Pharmacol. Ther. 19, 30 (2006) Prulifloxacin: a new antibacterial fluoroquinolone: G. Prats, et al.; Expert. Rev. Anti. Infect. Ther. 4, 27 (2006), (Review)

Physical State :
Solid
Solubility :
Soluble in DMF, 0.1M NaOH, and DMSO. Insoluble in water, and methanol.
Storage :
Store at -20° C
Melting Point :
211-214° C (dec.)
Boiling Point :
~633.2° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
pK Values :
pKa: 5.85 (Predicted), pKb: 6.25 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XJ0600000
PubChem CID :
65947
Merck Index :
14: 7908
MDL Number :
MFCD00864847
SMILES :
CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCN(CC4)CC5=C(OC(=O)O5)C

Download SDS (MSDS)

Certificate of Analysis

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