Proteasome Substrate II A fluorogenic substrate for proteosome II

Proteasome Substrate II (CAS 348086-66-8)

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Synonym: Z-Leu-Leu-Glu-7-amido-4-methylcoumarin
Application: A fluorogenic substrate for proteosome II
CAS Number: 348086-66-8
Molecular Weight: 664.8
Molecular Formula: C35H44N4O9
* Refer to Certificate of Analysis for lot specific data (including water content).
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Proteasome Substrate II is a fluorogenic substrate for the peptidylglutamyl-peptide hydrolyzing (caspase-like) activity of the proteasome. Can be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole.


References

Regulation of the peptidylglutamyl-peptide hydrolyzing activity of the pituitary multicatalytic proteinase complex.: M. Orlowski et al.; Biochemistry 30, 5999 (1991) Chemical modification of the bovine pituitary multicatalytic proteinase complex by N-acetylimidazole. Reversible activation of casein hydrolysis.: B. Yu et al.; J. Biol. Chem. 266, 17396 (1991) Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions.: M.E. Pereira et al.; Arch. Biochem. Biophys. 294, 1 (1992)Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome.: S. Tsubuki et al.; Biochem. Biophys. Res. Commun. 196, 1195 (1993)

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (50 mg/ml), and DMF.
Storage :
Store at -20° C
Boiling Point :
967.82° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
Fluoresence :
λex 380 nm, λem 460 nm
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
44135170
MDL Number :
MFCD01074989
SMILES :
CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

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