Proteasome Inhibitor II is a potent, cell-permeable, reversible proteasome inhibitor. The compound has been shown to inhibit chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Proteasome Inhibitor II blocks the decay of IkB-a and IkB-b proteins in exponentially growing WEHI 231 cells. The chemical has been shown not to inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC at concentrations as high as 200 µM.
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2. Orlowski, M., et al., 1997. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Biochemistry. 36(45): 13946-53. PMID: 9374874
3. Schauer, S L., et al., 1998. Dominant signals leading to inhibitor kappaB protein degradation mediate CD40 ligand rescue of WEHI 231 immature B cells from receptor-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950). 160(9): 4398-405. PMID: 9574544
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